Evidence map›Paper›PMID 41549645›Full record

ArticleBone & joint open2026

Risk factors for recurrence and complications of CT-guided radiofrequency ablation for the treatment of osteoid osteoma : a multi-institutional analysis.

Annabel M F Vennik, Marcos R Gonzalez, Alon G M Hopman, Lucy Hederick, Joseph J Connolly, Robert Hemke, IJsbrand Zijlstra, Connie Y Chang, Santiago A Lozano-Calderon, Floortje G M Verspoor

Abstract read
In one paragraph

Article in Bone & joint open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Annabel M F VennikOrthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Marcos R GonzalezOrthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Alon G M HopmanDepartment of Orthopedic Surgery and Sports Medicine, Cancer Center Amsterdam, Amsterdam University Medical Center Amsterdam, Amsterdam, Netherlands.
Lucy HederickOrthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Joseph J ConnollyOrthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Robert HemkeDepartment of Radiology, Amsterdam University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
IJsbrand ZijlstraDepartment of Radiology, Amsterdam University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Connie Y ChangDivision of Musculoskeletal Radiology, Department of Radiology, Massachusetts General Hospital, Boston, USA.
Santiago A Lozano-CalderonOrthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Floortje G M VerspoorDepartment of Orthopedic Surgery and Sports Medicine, Cancer Center Amsterdam, Amsterdam University Medical Center Amsterdam, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Radiofrequency ablation (RFA) is the gold standard for treating symptomatic osteoid osteoma (OO), yet risk factors for recurrence and complications remain poorly understood. This study aims to identify predictors of recurrence and local complications following RFA. Methods: A retrospective cohort study of OO patients treated with RFA at two academic medical centres between January 2010 and December 2024 was conducted. Primary outcomes were recurrence, defined as the return of symptoms with radiological confirmation, and post-procedural complications. Secondary outcomes included clinical success (complete pain resolution) and technical success (procedure done according to protocol). Descriptive, univariable, multivariable, and survival analyses were performed, with a sub-analysis of anterior tibial lesions. Results: A total of 272 patients were included. The median age was 20 years (IQR 16 to 26), and 189 of patients were male (69.5%). The most common locations for OO were the femur (41.9%, n = 114), tibia (26.5%, n = 72), and foot (11.4%, n = 31). The median tumour size was 7 mm (IQR 6 to 10) . Recurrence occurred in 5.5% (n = 15) of cases, with spinal location as a risk factor (odds ratio (OR) 6.22; p = 0.048). Complications were observed in 4% (n = 11) of patients, with increased risk in females (OR 5.17; p = 0.014) and those with tibial lesions (OR 13.23; p = 0.018). In tibial lesions, an anterior approach with the RFA probe was associated with a higher rate of wound infection (100% vs 0%; p = 0.028). Conclusion: RFA is a highly effective treatment for OO, with low rates of recurrence and complications. The identified risk factors underscore the need for tailored treatment plans. Furthermore, the anterior tibial approach should consistently incorporate a soft-tissue buffer to minimize the risk of wound infection.

Identifiers

PMID41549645
PMCPMC12813629

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.