Evidence map›Paper›PMID 41549632›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Noncovalent Click-to-Release Strategy to Control Bond Cleavage and Prodrug Activation.

Xuancheng Fu, Bowen Xu, Suman Maity, Michelle Wu, Luke G Westbrook, James H Henderson, Yaoying Wu, Katie A Edwards, Atanu Acharya, Xiaoran Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuancheng FuDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.ORCID 0000-0002-3402-943X
Bowen XuDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.
Suman MaityDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.
Michelle WuDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.
Luke G WestbrookDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.
James H HendersonBioInspired Institute, Syracuse University, Syracuse, New York, 13244, USA.ORCID 0000-0003-3355-5953
Yaoying WuBioInspired Institute, Syracuse University, Syracuse, New York, 13244, USA.ORCID 0000-0003-0570-2493
Katie A EdwardsDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, New York, 13902, USA.ORCID 0000-0002-8826-7863
Atanu AcharyaDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.
Xiaoran HuDepartment of Chemistry, Syracuse University, Syracuse, New York, 13244, USA.ORCID 0000-0001-7598-4516

Funding

National Science Foundation ACI-1341006Syracuse University
6 · The paper itself

Abstract

Click-to-release chemistry enables bioorthogonal bond cleavage and controlled release via a click-type ligation reaction serving as both the trigger and means of localization. Extending this concept beyond covalent ligation reactions, we introduce a noncovalent click-to-release strategy based on cucurbit[7]uril-adamantane (CB-Ad) association. The CB host molecule forms a pre-assembled host-guest complex with a self-immolative guest (SIG) SIG1, where the masked SIG remains inert. Introduction of a high-affinity guest Ad initiates the CB-Ad noncovalent click reaction, displacing SIG1 and triggering its self-immolation and cargo release. As a proof-of-concept, we used a prototype prodrug SIG2 to demonstrate our strategy's potential for controlled therapeutic release, effectively regulating the photodynamic cell killing in vitro. This noncovalent click-to-release approach broadens the structural and functional scope of bioorthogonal cleavage strategies with promising implications for stimuli-responsive materials and biomedical applications.

Indexed as

AdamantaneBridged-Ring CompoundsImidazolesProdrugsClick ChemistryCucurbit(n)urilsHumansMacrocyclic CompoundsMolecular StructureAdamantaneBridged-Ring Compoundscucurbit(7)urilCucurbit(n)urilsImidazolesMacrocyclic CompoundsProdrugsBioorthogonal cleavageClick to releaseHost‐guest systemsNoncovalent click chemistrySelf–immolative chemistry

Identifiers

PMID41549632
PMCPMC12930019

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.