Protective Effect of Brain Derived Neurotrophic Factor-Overexpressing Wharton's Jelly-Derived Mesenchymal Stromal Cells in Severe Intraventricular Hemorrhage in Newborn Rats.

So Yeon Jung, Misun Yang, Young Eun Kim, Dong Kyung Sung, Se In Sung, Chang-Woo Lee, Yun Sil Chang, So Yoon Ahn

Abstract read

In one paragraph

Article in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

So Yeon JungCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0001-8201-008X

Misun YangCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-1634-6623

Young Eun KimCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0008-1881-3671

Dong Kyung SungCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0008-8073-9636

Se In SungCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8717-6142

Chang-Woo LeeDepartment of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-0943-1646

Yun Sil ChangCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-9201-2938

So Yoon AhnCell and Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-1821-3173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain-derived neurotrophic factor (BDNF) plays a crucial role in neuroprotection, and we have previously demonstrated BDNF-mediated neuroprotective effects in mesenchymal stromal cells (MSCs). The present study aimed to investigate whether BDNF-overexpressing MSCs enhance the therapeutic efficacy of naïve MSCs in a preclinical model of severe neonatal intraventricular hemorrhage (IVH). We exposed primary rat neuronal cells to 40 U of thrombin overnight

Indexed as

Brain-derived neurotrophic factorCerebral intraventricular hemorrhageMesenchymal stromal cellsPreterm infants

Identifiers

PMID41549589

DOI10.15283/ijsc25016

PMCPMC12954765

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.