Cyclodextrin and KR12-Lipopeptide Interactions: A Thermodynamic View of Binding Mechanisms and Impact on the Structure of α-Helical Peptides.

Martyna Kapica, Ola Grabowska, Elżbieta Kamysz, Julia Kamysz, Sergey A Samsonov, Dariusz Wyrzykowski

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Article in The journal of physical chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Martyna KapicaFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.

Ola GrabowskaFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.

Elżbieta KamyszFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.

Julia KamyszInter-faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Stefana Banacha 2C, 02-097 Warsaw, Poland.

Sergey A SamsonovFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-5166-4849

Dariusz WyrzykowskiFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-3823-3286

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural antimicrobial peptides are a promising new class of antibiotics that offer a potential response to the growing challenge of microbial resistance. Among these, lipopeptides─cationic peptides conjugated with fatty acid residues─are especially noteworthy as their tendency to form α-helical structures plays a crucial role in determining their biological effectiveness. The ability to adopt an ordered structure, which directly influences their antimicrobial action, is determined by the length of the conjugated alkyl chain. In this study, experimental methods (isothermal titration calorimetry and circular dichroism), complemented by in silico analysis, have been successfully applied to rigorously characterize the interactions between three types of cyclodextrin (α-, ß-, and γ-) and three variants of antimicrobial KR12-lipopeptides, namely, the octanoylated (C8-KR12-NH

Indexed as

CyclodextrinsLipopeptidesThermodynamicsCircular DichroismProtein BindingProtein Conformation, alpha-HelicalCyclodextrinsLipopeptides

Identifiers

PMID41549521

DOI10.1021/acs.jpcb.5c06749

PMCPMC13296729

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