ArticleDevelopmental medicine and child neurology2026
Disproportional ventilatory response to incremental exercise in individuals with cerebral palsy.
Article in Developmental medicine and child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Physiological determinants of endurance capacity in individuals with cerebral palsy: a narrative review.Journal of rehabilitation medicine · 2026Review
- Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.Experimental physiology · 2026Article
- Lung function and ventilatory response during high-intensity treadmill walking in adults with cerebral palsy: a cross-sectional study.Journal of rehabilitation medicine · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
aimTo explore the integrated cardiopulmonary, metabolic, and muscular response to incremental exercise in individuals with cerebral palsy (CP) compared with typically developing participants.
methodThis was a prospective cross-sectional study. Sixteen (seven male) individuals with CP (classified in Gross Motor Function Classification System levels II-V) and 30 (15 male) typically developing participants performed a treadmill-based incremental submaximal test and an exercise test to task failure. Participants used running frames (CP) or performed traditional running (typically developing participants). Metabolic and cardiopulmonary parameters were measured during both tests. Electromyography of the vastus lateralis and gastrocnemius medialis was recorded during the test to task failure.
resultsCompared with typically developing participants, individuals with CP showed decreased minute ventilation (p < 0.05), increased respiratory frequency at a comparable exercise intensity (p < 0.05), and an altered metabolic response, on the basis of the partial pressure of carbon dioxide (p < 0.05) and lactate levels (p < 0.001), during both tests. In addition, participants with CP exhibited a lower ventilatory efficiency during the test to task failure (p < 0.01). Electromyography analysis suggested peripheral skeletal muscle fatigue in the lower limbs (p < 0.05) in individuals with CP compared with typically developing participants.
interpretationIndividuals with CP have a disproportional ventilatory response to incremental exercise, not driven by metabolic perturbations. The increased breathing frequency resulted in high rate of perceived exertion and signs of peripheral muscle fatigue compared with typically developing participants. Our findings stress the importance of interventions focused on ventilatory function in individuals with CP.
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