ArticleOral diseases2026
Traumatic Ulcerative Granuloma With Stromal Eosinophilia: Clinico-Pathologic and Molecular Analysis.
Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis study aimed to retrospectively analyze the prevalence and clinical characteristics of TUGSE and explore the potential role of viral agents in these lesions.
methodsFifty-seven TUGSE and 50 non-specific ulcer patients were included. Patient demographic and clinical data were collected. Formalin-fixed paraffin-embedded tissues were screened by PCR for Epstein-Barr virus (EBV), cytomegalovirus (hCMV), human papillomavirus (HPV), herpes simplex virus (HSV), and Helicobacter pylori (H. pylori).
resultsThe majority of TUGSE patients were in their sixth (29.8%) and seventh (24.6%) decades of life, with a 1:1.6 male-to-female ratio. The tongue is the most common site (47.4%), followed by buccal mucosa (28.1%). The average duration was 13.5 weeks, and almost one-fourth of the lesions were clinically diagnosed as oral squamous cell carcinoma (24.6%). TUGSE showed a significantly higher propensity to harbor macrophage infiltrates and inflammatory involvement with skeletal muscle fibers or salivary gland tissues, compared to non-specific ulcers. EBV was observed in two TUGSE cases (3.5%) and one patient with a non-specific ulcer (2.0%). Other viral agents were undetectable in TUGSE.
conclusionTUGSE frequently affects the elderly population with a female predilection. The observed low prevalence of viral agents suggests that these pathogens may not play a direct role in TUGSE development.
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