ArticleThe international journal of cardiovascular imaging2026
Feasibility of using synthetic myocardial extracellular volume fraction derived from blood CT attenuation for the differentiation of heart failure.
Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To evaluate the feasibility of using synthetic extracellular volume (sECV) fraction-calculated from synthetic hematocrit (sHCT) derived via blood CT attenuation-as an alternative for conventional ECV in differentiation heart failure (HF). This study prospectively included 120 patients undergoing calcium scoring (CS), coronary CT angiography (CCTA), and late enhancement (LE) imaging (5 min after CCTA), with HCT measured within 24 h. Conventional ECV (cECV) was calculated using serum HCT. An additional retrospective cohort of 207 patients with CS and HCT was analyzed. Linear regression was used to derive sHCT from blood CT attenuation in the left ventricle (LV), right ventricle (RV), and ascending aorta (AO), enabling calculation of sHCT fractions (sECV
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