Observational studyAnnals of clinical and translational neurology2026
Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy.
Observational study in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy.Annals of clinical and translational neurology · 2026Observational
- Magnetic resonance imaging in Parkinson's disease: from routine imaging to molecular biomarkers - an update for radiologists.Polish journal of radiology · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
introductionProgressive Supranuclear Palsy (PSP) is a neurodegenerative 'tauopathy' with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal. We hypothesise that volume loss is appreciable in the cerebellum and brainstem regions-beyond the midbrain-in individuals with PSP and linked to motor and non-motor clinical features.
methodsIn this cross-sectional observational study, volumetric brainstem and cerebellar subsegmentation of T1-weighted magnetic resonance imaging (MRI) was performed in 37 adults with PSP. Group-level comparisons were made with 38 adults with Parkinson's disease (PD) and 35 healthy control (HC) subjects. Regional volumes in the PSP cohort were correlated against disease severity and cognition.
resultsCompared with HC, the midbrain, corpus medullare, and flocculonodular lobe were smaller in PSP (d = 0.90-1.2). Compared with PD, the midbrain, pons, and superior cerebellar peduncle (SCP) were smaller in PSP (d = 0.82-1.9). There was a positive correlation between the frontal assessment battery (FAB) and volume of the superior (r = 0.50) and inferior (r = 0.48) cerebellar posterior lobes. The PSP rating scale also correlated with SCP (r = -0.58) and midbrain (r = -0.52) volume.
conclusionAdditional regions of brainstem and cerebellar volume loss, alongside midbrain atrophy, were observed in PSP. The reported clinico-radiologic correlations suggest a role of the cerebellum in cognitive dysfunction. These findings indicate that the cerebellum is not spared and support further work to understand the temporal course of cerebellar and cerebellar connectivity changes relative to other brain regions.
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