SynthesisAddiction (Abingdon, England)2026
Gender differences in the impact of psychological distress on methamphetamine use disorder outcomes and treatment effect.
Synthesis in Addiction (Abingdon, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
aimsMethamphetamine use disorder (MUD) is a major public health concern, often complicated by co-occurring psychological distress (PD). Evidence suggests gender differences in both the prevalence of PD and its impact on treatment outcomes. This study examined impacts of PD on MUD treatment outcomes, focusing on gender differences.
designSecondary analysis of pooled data from five randomized controlled trials of pharmacotherapy for MUD available on the NIDA DataShare site (accessed 19 October 2024). Individual participant data meta-analysis methods were used, adjusting for sociodemographic factors and accounting for heterogeneity across trials. Regression analyses were conducted for total sample and stratified by gender.
settingTreatment facilities in the US.
participantsAdults seeking MUD treatment (n = 866). MEASUREMENTS: PD was assessed using the Addiction Severity Index psychiatric domain (≥24.6 cutoff). Outcomes included reductions in methamphetamine use and positive urine tests for methamphetamine and other drugs.
findingsPD was found in 39.9% of participants. PD was more common among women than men [odds ratio (OR) = 1.56, 95% confidence interval (CI) = 1.15-2.12], and among individuals who were younger (ages 35-45 vs. <35: OR = 0.72, 95% CI = 0.61-0.85; >45 vs. < 35: OR = 0.62, 95% CI = 0.44-0.88), had lower education (OR = 1.38, 95% CI = 1.16-1.65), chronic medical conditions (OR = 1.60, 95% CI = 1.16-2.20), history of injection drug use (OR = 1.47, 95% CI = 1.13-1.91) and prior treatment for alcohol use disorder (OR = 2.52, 95% CI = 1.64-3.84). PD was associated with lower odds of reduced use [adjusted OR (aOR) = 0.74, 95% CI = 0.66-0.82] and higher odds of positive methamphetamine urine tests (aOR = 1.27, 95% CI = 1.08-1.49). Stratified analyses revealed a stronger association among women between PD and lower odds of reduced use (aOR = 0.41, 95% CI = 0.23-0.75) and higher odds of positive urine tests for methamphetamine (aOR = 2.18, 95% CI = 1.25-3.81) and other drugs (aOR = 3.16, 95% CI = 1.53-6.47), whereas men showed no statistically significant impact of PD on treatment outcomes. A statistically significant interaction between treatment, gender and PD (P < 0.001) indicated that women without PD benefited more from treatment than those with PD, a pattern not mirrored in men.
conclusionPsychological distress appears to negatively impact outcomes for MUD and the effects of MUD treatment, particularly among women. Integrated psychological interventions, tailored by gender, may enhance treatment efficacy for individuals with co-occurring MUD and psychological distress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.