Evidence map›Paper›PMID 41548870›Full record

ArticleJournal of advanced research2026

TNFSF10 drives hyperactive immune responses via NLRP3 inflammasome and endoplasmic reticulum stress in autoimmune and inflammatory diseases.

Huilin Zhang, Yaoyao Chen, Yingmei Li, Chang Chen, Bingjie Wang, Fanxiang Yin, Yunling Zhu, Jiani Li, Jin Li, Ping Tang and 9 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Huilin ZhangTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yaoyao ChenTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yingmei LiDepartment of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Chang ChenTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Bingjie WangTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Fanxiang YinTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yunling ZhuTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Public Research Platform Management Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Critical Care Medicine, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China; Institute of Infection and Immunity, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan, China.
Jiani LiTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jin LiTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Ping TangDepartment of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Juanxia ZhouDepartment of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Shaohua YanTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Bo QinTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Qingxuan XinDepartment of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Shuya WangDepartment of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Qiankun YangDepartment of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Baohong YueDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: fccybh@zzu.edu.cn.
Yong JiangPublic Research Platform Management Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Critical Care Medicine, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China; Institute of Infection and Immunity, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan, China; Department of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China. Electronic address: jiang48231@163.com.
Rongqun GuoTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Public Research Platform Management Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China. Electronic address: guorq2007@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutoimmune and inflammatory diseases are characterized by multifaceted pathogenesis, demanding effective therapeutic strategies.

objectivesTNFSF10 is typically regarded as a pro-apoptotic ligand, yet its functions under physiological and pathological conditions remain elusive.

methodsscRNA-seq analysis of immune cells from patients with aplastic anemia (AA) was performed to identify the crucial DEGs,with TNFSF10 being highlighted as a key regulator. Tnfsf10-deficient mice were used to establish an AA mouse model, and other mouse models, such as ER stress, aGVHD, radiation-induced aging, and IBD, which facilitated the exploration of the biological function of TNFSF10.

resultsHere, we show that TNFSF10 contributes to the imbalance of immune homeostasis and immunogenic cell death (ICD) under pathological circumstances. The ICD-provoking effect and proinflammatory property of TNFSF10 is associated with the activation of the NF-κB pathway and NLRP3 inflammasome. Additionally, TNFSF10 is a crucial amplifier of endoplasmic reticulum stress by enhancing the expression of PPP1R15A, thereby contributing to NLRP3 inflammasome activation. Moreover, TNFSF10-associated ER stress is a driver of surface Calreticulin (CALR) exposure, which transmits an "eat me" signal to hyperactivated immune cells and accelerates the clearance of hematopoietic cells. We also found that AA-specific exosomes may contribute to ER stress and the expression of TNFSF10.

conclusionCollectively, our study reveals the key role of TNFSF10 in autoimmune and inflammatory diseases, integrating the NF-κB, NLRP3 inflammasome, and ER stress pathways, and further accelerating the disease process.

Indexed as

Anemia, AplasticAutoimmune DiseasesEndoplasmic Reticulum StressInflammasomesInflammationNLR Family, Pyrin Domain-Containing 3 ProteinTNF-Related Apoptosis-Inducing LigandAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutNF-kappa BSignal TransductionInflammasomesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinTNF-Related Apoptosis-Inducing LigandAplastic anemiaAutoimmune and inflammatory diseasesNLRP3PPP1R15ATNFSF10

Identifiers

PMID41548870
PMCPMC13669606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.