Evidence map›Paper›PMID 41548838›Full record

ArticleJournal of pediatric surgery2026

Growth failure and early recurrence in congenital diaphragmatic hernia: An international cohort study.

Rachel C Bordelon, Kylie I Holden, Charles C Miller, Ashley H Ebanks, Kevin P Lally, Matthew T Harting, Allison L Speer, Representing the Congenital Diaphragmatic Hernia Study Group

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel C BordelonDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Suite 5.258, Houston, TX, 77030, USA. Electronic address: Rachel.C.Bordelon@uth.tmc.edu.
Kylie I HoldenDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Suite 5.258, Houston, TX, 77030, USA.
Charles C MillerDepartment of Cardiothoracic and Vascular Surgery, McGovern Medical School at the University of Texas Health Science Center, 6400 Fannin Street, Houston, TX, 77030, USA; Center for Clinical Research and Evidence-Based Medicine, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Houston, TX, 77030, USA.
Ashley H EbanksDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Suite 5.258, Houston, TX, 77030, USA.
Kevin P LallyDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Suite 5.258, Houston, TX, 77030, USA.
Matthew T HartingDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Suite 5.258, Houston, TX, 77030, USA.
Allison L SpeerDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, Suite 5.258, Houston, TX, 77030, USA; Short Bowel Syndrome Therapy and Rehabilitation (STAR) Team, McGovern Medical School at the University of Texas Health Science Center and Children's Memorial Hermann Hospital, 6431 Fannin Street, Houston, TX, 77030, USA.
Representing the Congenital Diaphragmatic Hernia Study Group

Funding

Enteric Nervous System Development and Function in Human Intestinal OrganoidsK08DK131326 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Allison Leigh Speer · 2022 to 2026
$768k
NIDDK NIH HHS K08 DK131326
6 · The paper itself

Abstract

purposeThe primary objective was to determine whether growth failure (GF) is associated with early recurrence in congenital diaphragmatic hernia (CDH). The secondary objective was to characterize the prevalence and severity of GF in CDH survivors.

backgroundGF is common among CDH survivors, yet it is unclear how growth challenges affect overall morbidity, including hernia recurrence. CDH-specific nutritional guidelines include high calorie and protein targets during periods of acute illness but may benefit from clarifying the relationship between growth and adverse outcomes in this population.

methodsThis multicenter cohort study retrospectively analyzed prospectively collected data from the CDH Study Group (CDHSG) registry. Weight-for-age Z-scores (WAZ) were calculated for CDH survivors born between 2007 and 2023 and GF was defined as WAZ <-2.0 at discharge from birth admission. Non-parametric tests and logistic regression analyses were employed.

resultsAmong 4931 CDH survivors, median gestational age and birth weight were 38 weeks and 3.1 kg, respectively (birth WAZ -0.24). Left-sided defects predominated (4205), with expected distribution by CDHSG stage: A (16 %), B (44 %), C (31 %), D (8 %). GF occurred in 14.6 % (720). Hernia recurrence occurred in 3.3 % (163), more commonly in those with GF: 6.4 % (46/720) versus 2.8 % (117/4211) (p < 0.001). GF patients had 80 % increased odds of early recurrence (adjusted odds ratio 1.8; 95 % CI 1.2-2.4; p = 0.007).

conclusionsGF is a potentially modifiable risk factor for early CDH recurrence, underscoring the need for targeted nutritional protocols. Future studies should evaluate center-specific practices and assess long-term recurrence risk related to nutrition and growth.

Indexed as

Growth DisordersHernias, Diaphragmatic, CongenitalCohort StudiesFemaleGestational AgeHumansInfant, NewbornMalePrevalenceRecurrenceRegistriesRetrospective StudiesSeverity of Illness IndexCongenitalDiaphragmaticGrowthHerniaHernia recurrenceInfant

Identifiers

PMID41548838
PMCPMC13186048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.