Evidence map›Paper›PMID 41548195›Full record

ArticleAmerican journal of primatology2026

Next-Generation Short-Read Sequencing Reveals Impacts on Major Histocompatibility Complex Diversity Resulting From Differences in Captive Rhesus Macaque (Macaca Mulatta) Colony Expansion Strategies.

Sreetharan Kanthaswamy, Roger W Wiseman, Miranda R Stauss, Max C Ertl, Divy K Patel, David G Smith, Melween I Martínez, Elizabeth Maldonado, Carlos A Sariol

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of primatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sreetharan KanthaswamyCalifornia National Primate Research Center, University of California, Davis, California, USA.ORCID 0009-0000-0313-5566
Roger W WisemanWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Miranda R StaussWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Max C ErtlWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Divy K PatelSchool of Mathematics and Natural Sciences, Arizona State University (ASU), Glendale, Arizona, USA.
David G SmithCalifornia National Primate Research Center, University of California, Davis, California, USA.
Melween I MartínezCaribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.
Elizabeth MaldonadoCaribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.
Carlos A SariolCaribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Viral TestingU42OD021458 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2016 to 2026
$45.1M
Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
NIH HHS P40 OD012217NIH HHS P51 OD011106NIH HHS U42 OD021458ORIP NIH HHS 5P40OD012217ORIP NIH HHS 5U42OD021458-16
6 · The paper itself

Abstract

The Caribbean Primate Research Center's (CPRC) specific-pathogen-free (SPF) rhesus macaque (Macaca mulatta) colony was established between 1998 and 2002 with 87 founders from Cayo Santiago. Colony expansion continued with the rederivation of animals from their SPF predecessors, while additional animals were still being relocated from Cayo Santiago. The CPRC's major histocompatibility complex (MHC) database, generated through next-generation short-read sequencing, provides insights into the long-term MHC immunogenetics of its SPF colony. This database was used to examine the composition of Mamu-A, Mamu-B (Class I), and Mamu-DRB (Class II) across five 5-year SPF birth cohorts from 1998 to 2022. Population structure at these loci was compared with that of 27 non-syntenic short tandem repeats (STRs) to examine longitudinal differences in MHC and STR composition during the colony's transition from establishment to expansion. There was no significant relationship between the average observed (OH) and expected (EH) heterozygosity values of the STRs and those of the MHC. STRs exhibited greater and more consistent heterogeneity. Besides being lower than the STRs, the longitudinal changes in the MHC's EH were more pronounced. The pattern of pairwise differentiation (F

Indexed as

Genetic VariationMacaca mulattaMajor Histocompatibility ComplexAnimalsFemaleHigh-Throughput Nucleotide SequencingMaleMicrosatellite RepeatsSpecific Pathogen-Free Organismscaptive breedinggenetic managementmajor histocompatibility complexnext‐generation sequencing (NGS)SPF colony

Identifiers

PMID41548195
PMCPMC12977098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.