Evidence map›Paper›PMID 41548123›Full record

ArticleOncoimmunology2026

NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells.

Lukas Heger, Tomasz Kaszubowski, Lukas Amon, Christian H K Lehmann, Susanne Wingert, José Medina-Echeverz, Joachim Koch, Holger Hackstein, Ariawan Purbojo, Arndt Hartmann and 4 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lukas HegerDepartment of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.ORCID 0000-0001-5591-2187
Tomasz KaszubowskiDepartment of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Lukas AmonDepartment of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Christian H K LehmannDepartment of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Susanne WingertAffimed GmbH, Mannheim, Germany.
José Medina-EcheverzAffimed GmbH, Mannheim, Germany.ORCID 0000-0002-6160-8840
Joachim KochAffimed GmbH, Mannheim, Germany.
Holger HacksteinDepartment of Transfusion Medicine and Hemostaseology, FAU Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Ariawan PurbojoDepartment of Pediatric Cardiac Surgery, FAU Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Arndt HartmannDepartment of Pathology, FAU Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Christoph AlexiouDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, University Hospital Erlangen, Erlangen, Germany.
Robert CesnjevarDepartment of Pediatric Cardiac Surgery, FAU Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.
Jens PahlAffimed GmbH, Mannheim, Germany.
Diana DudziakDepartment of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bispecific antibodies are used for the treatment of hematological malignancies as well as solid tumors. One of their main effector mechanisms is the recruitment of effector cells such as CD8

Indexed as

Antibodies, BispecificAntibody-Dependent Cell CytotoxicityDendritic CellsKiller Cells, NaturalCell Line, TumorHumansImmunity, InnateLymphocyte ActivationAntibodies, BispecificADCCAFM24Bispecific antibodiesCD16AcDC1DC2DC3dendritic cellsEGFRNK cell

Identifiers

PMID41548123
PMCPMC12818816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.