Evidence map›Paper›PMID 41548059›Full record

ArticleChemistry & biodiversity2026

Design, Synthesis, and Integrated Computational Evaluation of Novel Quinoline Hydrazones as Dual-Action Anti-Inflammatory and Antibacterial Agents.

Bachir Douara, Katia Mohand Saidi, Lotfi Belkhiri, Nassima Boutaoui, Mohamed Zakaria Stiti, Smail Khelili, Ramzi Maadadi, Abdelmadjid Guendouzi, Abdelkrim Guendouzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bachir DouaraLaboratoire de Phytochimie et de Pharmacologie, Département de Chimie, Faculté des Sciences Exactes et Informatique, Université de Jijel, Jijel, Algeria.ORCID https://orcid.org/0000-0002-2864-9827
Katia Mohand SaidiLaboratoire de Phytochimie et de Pharmacologie, Département de Chimie, Faculté des Sciences Exactes et Informatique, Université de Jijel, Jijel, Algeria.ORCID https://orcid.org/0009-0006-6894-0551
Lotfi BelkhiriCentre de Recherche en Sciences Pharmaceutiques CRSP, ZAM Ali Mendjeli, Constantine, Algeria.ORCID https://orcid.org/0000-0002-6093-6965
Nassima BoutaouiLaboratoire de Phytochimie et de Pharmacologie, Département de Chimie, Faculté des Sciences Exactes et Informatique, Université de Jijel, Jijel, Algeria.ORCID https://orcid.org/0000-0001-6434-664X
Mohamed Zakaria StitiLaboratoire de Phytochimie et de Pharmacologie, Département de Chimie, Faculté des Sciences Exactes et Informatique, Université de Jijel, Jijel, Algeria.ORCID https://orcid.org/0000-0002-5504-9827
Smail KheliliLaboratoire de Phytochimie et de Pharmacologie, Département de Chimie, Faculté des Sciences Exactes et Informatique, Université de Jijel, Jijel, Algeria.ORCID https://orcid.org/0000-0002-7343-0242
Ramzi MaadadiCentre de Recherche en Sciences Pharmaceutiques CRSP, ZAM Ali Mendjeli, Constantine, Algeria.ORCID https://orcid.org/0000-0002-1795-1684
Abdelmadjid GuendouziLaboratoire de Chimie, Synthèse, Propriétés et Applications LCSPA, Département de Chimie, Faculté des Sciences, Université de Saida, Saida, Algeria.ORCID https://orcid.org/0000-0001-7138-787X
Abdelkrim GuendouziURCHEMS, Département de Chimie, Université Constantine 1 Frères Mentouri, Constantine, Algeria.ORCID https://orcid.org/0000-0001-9476-0489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Addressing both bacterial infections and inflammation necessitates the development of innovative therapeutic strategies that mitigate the risks associated with polypharmacy. The targeted quinoline hydrazone derivatives (6a-j) were synthesized via a two-step process, beginning with the preparation of the essential quinoline hydrazide intermediate 5, followed by its condensation with substituted aromatic aldehydes. Advanced spectroscopic techniques, including

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalDrug DesignHydrazonesQuinolinesAnimalsCyclooxygenase 2Density Functional TheoryDNA GyraseEscherichia coliHumansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureAnti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2DNA GyraseHydrazonesquinolineQuinolinesantibacterial activityanti‐inflammatory activityin silico investigationsmultifunctional medicinal agentsquinoline hydrazones

Identifiers

PMID41548059
PMCPMC13420800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.