SynthesisEye (London, England)2026
The effect of selective laser trabeculoplasty on the intraocular pressure of the contralateral eye - a systematic review and meta-analysis.
Synthesis in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
This systematic review and meta-analysis assesses the effect of unilateral selective laser trabeculoplasty (SLT) in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) eyes on contralateral eye intraocular pressure (IOP). A literature search was performed in PubMED, EMBASE, and Cochrane Library. We included all English randomised controlled trials, retrospective and prospective cohort studies, cross-sectional studies and case series published between 29 August 2004 and 29 August 2024 that performed unilateral SLT in POAG or OHT eyes with contralateral eye IOP reported at least 3 months after SLT. Risk of bias was assessed using the ROBINS-I tool. Meta-analysis was performed using the random-effects model and presented as forest plots. 9 studies (478 eyes) were included in the final pooled analysis, which demonstrated a mean contralateral IOP reduction of 1.85 mmHg (95% CI [1.23, 2.47]) 3-6 months after SLT. Subgroup analysis found a mean contralateral IOP reduction of 2.21 mmHg (95% CI [1.06, 3.36]) and 2.29 mmHg (95% CI [1.30, 3.29]) 3-6 months following 360° (4 studies, 264 eyes) and 180° SLT (2 studies, 55 eyes) respectively; there was no significant difference between both groups (p = 0.91). Meta-correlation analysis of 3 studies (160 eyes) found moderate positive correlation between IOP reduction in SLT-treated and contralateral eyes at 3-6 months (pooled Pearson's R = 0.65, 95% CI [0.54, 0.73]). Our meta-analysis suggests statistically significant contralateral IOP reduction 3-6 months following unilateral SLT, which was correlated with IOP reduction of SLT-treated eyes. These findings may have implications on future SLT studies and real-life clinical practice.Review Registration The protocol for this review was registered with PROSPERO (ID: CRD420251013653).
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