Evidence map›Paper›PMID 41547963›Full record

ArticlePediatric research2026

A-Maze-Ox: a novel gas-exchange-area-adjustable oxygenator for extremely preterm infants-design and proof of concept.

Franziska Schubert, Jan Heyer, Maximilian Lunemann, Jutta Arens, Ulrich Steinseifer, Sebastian Victor Jansen, Mark Schoberer

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Franziska SchubertDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany. schubert@ame.rwth-aachen.de.
Jan HeyerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Maximilian LunemannDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Jutta ArensEngineering Organ Support Technologies, Faculty of Engineering Technology, Department of Biomechanical Engineering, University Twente, Enschede, Overijssel, Netherlands.
Ulrich SteinseiferDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Sebastian Victor JansenDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Mark SchobererPediatric Clinic, Neonatology Section, Medical Faculty, RWTH Aachen University and University Hospital, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEach year, over half a million children worldwide are born extremely prematurely (EPI), often requiring potentially harmful ventilatory support. An artificial placenta with gas exchange provided by an oxygenator offers an alternative. However, current oxygenators are not designed for long-term applications in patients experiencing growth. Thus, a new type of "growing" oxygenator is needed.

methodsWe developed the A-Maze-Ox, a novel maze-inspired membrane oxygenator featuring two concentric compartments that can be opened sequentially to address patient growth. Each compartment has a priming volume of 5 mL and a gas exchange area of 0.065 m². The prototype was tested for feasibility, gas transfer performance and pressure loss according to ISO 7199.

resultsAdding the second compartment increased O

conclusionsThe A-Maze-Ox demonstrates the ability to adapt to increasing demands with good results in CO IMPACT: Current oxygenators cannot adapt to the dynamic patient growth of extremely premature infants. A-Maze-Ox-a novel membrane oxygenator with two compartments can adapt to growth. Each compartment has a volume of 5 mL and a gas exchange area of 0.065 m². Oxygen transfer increased by 57.06% and carbon dioxide transfer by 35.59% when adding the second compartment. A-Maze-Ox could improve health of extremely premature infants in the future.

Indexed as

Infant, Extremely PrematureOxygenators, MembranePulmonary Gas ExchangeCarbon DioxideEquipment DesignFemaleHumansInfant, NewbornOxygenProof of Concept StudyCarbon DioxideOxygen

Identifiers

PMID41547963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.