Evidence map›Paper›PMID 41547939›Full record

ArticleScientific reports2026

Exploration of potential biomarkers in salivary duct carcinoma based on bioinformatics analysis.

Ruiqi Zhang, Xingyao Zhu, Hongmei Ma, Ercan Sun, Xueping Xiang, Fengbo Huang, Bo Hong, Yuhua Liu, Hong Zou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruiqi Zhang *Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, 310009, China.
Xingyao Zhu *Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, 310009, China.
Hongmei Ma *Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital，Southern Medical University，, Shenzhen，Guangdong Province, 518000, China.
Ercan SunHead and Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, 310009, China.
Xueping XiangDepartment of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, 310009, China.
Fengbo HuangDepartment of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, 310009, China.
Bo HongDepartment of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, 310009, China.
Yuhua LiuDepartment of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang, 832002, China.
Hong ZouDepartment of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, 310009, China. zouhong@zju.edu.cn.

Funding

Basic Public Welfare Research Program of Zhejiang Province LY23H160012National Natural Science Foundation of China 82373176
6 · The paper itself

Abstract

Salivary duct carcinoma (SDC) is a rare and aggressive malignant tumor, with scarce reports on its pathogenesis and treatment methods. This study aims to explore the potential biomarkers of SDC. SDC cases were analyzed using Illumina microarrays, and Limma identified differentially expressed genes (DEGs) between cancer and normal tissues. An intersection of these DEGs with the differential genes from the GSE138581 dataset was obtained through Venn analysis to identify the core DEGs. The core DEGs were analyzed by search Tool for the retrieval of interacting genes/proteins (STRING) and cytoscape to identify the genes most related to the disease in SDC patients. Core genes were enriched with gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG); their pan-cancer implications and immune aspects were studied. Finally, the core DEGs were initially validated by immunohistochemistry in SDC samples. Fifty DEGs were found by exome sequencing, 3158 by the GSE138581 microarray. Thirteen common genes were identified by Venn analysis, and ten core genes, including Forkhead box M1 (FOXM1), collagen, type XI, alpha 1 (COL11A1), and neuron navigator 2 (NAV2), were selected. GO enrichment of core genes included positive regulation of calcium ion transport and ATPase activity, and KEGG analysis focused on related pathways. Expression was evaluated across 34 cancers from the TCGA database, and immune DEG Phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5) was identified. The obtained DEGs were further validated by immunohistochemistry (IHC). Identifying the DEGs not only helps improve our understanding of SDC pathogenesis but also promises to identify potential biomarkers and new therapeutic targets.

Indexed as

Biomarkers, TumorComputational BiologySalivary DuctsSalivary Gland NeoplasmsCollagen Type XIGene Expression ProfilingGene Expression Regulation, NeoplasticGene OntologyGene Regulatory NetworksHumansBiomarkers, TumorCOL11A1 protein, humanCollagen Type XIBioinformatics analysisDifferentially expressed genesExon microarraySalivary duct carcinoma

Identifiers

PMID41547939
PMCPMC12886760

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