ReviewHuman genomics2026
Charting exposomethics: a roadmap for the ethical foundations of the human exposome project.
Review in Human genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- The diabetes exposome: interplay of environmental and genetic determinants in diabetes.Human genomics · 2026Review
- The Digital Exposome: A Life Course Framework for Health in the Digital Age.Journal of medical Internet research · 2026Article
- AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project.Frontiers in public health · 2026Review
- The data substrate of exposome intelligence: an interoperability profile for untargeted metabolomics.Frontiers in artificial intelligence · 2026Article
- Navigating the AI Frontier in Toxicology: Trends, Trust, and Transformation.Current environmental health reports · 2025Review
- Microphysiological systems as a pillar of the Human Exposome Project.The Journal of biological chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe Human Exposome Project (HEP) aims to chart lifelong environmental exposures and their biological consequences, furnishing the environmental counterpart to the genomic revolution. Yet the fine‑grained, multimodal data streams that fuel exposomics-biospecimens, geolocation traces, wearable‑sensor feeds, and socio‑environmental metadata-raise privacy, justice, and governance questions that may exceed the reach of conventional bioethics. MAIN BODY: Building on lessons from genomics, biobanking, digital health, and environmental‑justice research, we identify five foundational ethical domains for exposome science: (1) privacy and data sovereignty, (2) informed consent and sustained participant engagement, (3) environmental justice, (4) governance and oversight, and (5) actionability and the responsible return of results,as well as (6)the adherence to research program goals. Similar to the "values in design" construct widely used in the socio-technical field and the "ethics by design" in the artificial intelligence (AI) field, we translate these domains into operational pillars for ethics‑by‑design research practice: dynamic or tiered consent architectures; participatory governance mechanisms such as community advisory boards; embedded ethics research programs; algorithmic‑fairness protocols for artificial‑intelligence analytics; and dedicated review bodies equipped to evaluate longitudinal, sensor‑based, multi‑omics studies. Concrete recommendations include federated data stewardship to minimize re‑identification risk, Evidence‑to‑Decision frameworks that couple exposomic evidence with societal values, and transparent pathways for communicating context‑dependent findings to individuals, communities, and policymakers.
conclusionsEthical preparedness and action are a prerequisite for the scientific impact and social license of exposome research. Institutionalizing the proposed roadmap-via an international Exposome Ethics Consortium, expanded training for Institutional Review Boards, harmonized regulatory guidance, and sustained community co‑governance-will help protect privacy, promote equity, and foster public trust. Embedding systematic ethical reflection as core infrastructure will enable the Human Exposome Project to realize its promise of precision public health without replicating patterns of opaque surveillance, marginalization, or data commodification. The Human Exposome Project (HEP) represents an ambitious endeavor to characterize lifelong environmental exposures in relation to health. Yet, this vision brings profound ethical challenges: from managing massive, sensitive datasets to ensuring justice for disproportionately exposed communities. This article synthesizes foundational work on exposome ethics, outlines core ethical challenges, and proposes a proactive ethical governance model that ensures scientific integrity and social legitimacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.