Evidence map›Paper›PMID 41547910›Full record

ArticleNature communications2026

Aperiodic 1/f noise drives ripple activity in humans.

Frank J van Schalkwijk, Randolph F Helfrich

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Frank J van SchalkwijkHertie-Institute for Clinical Brain Research, Center for Neurology, University Hospital Tübingen, Tübingen, Germany. frankvanschalkwijk@gmail.com.ORCID http://orcid.org/0000-0001-8291-652X
Randolph F HelfrichDepartment of Psychology, Yale University, New Haven, CT, USA. randolph.helfrich@gmail.com.ORCID http://orcid.org/0000-0001-8045-3111

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) DFG HE8329/2-1Deutsche Forschungsgemeinschaft (German Research Foundation) DFG SCHA 2369/1-1
6 · The paper itself

Abstract

Sharp-wave ripples (SWR) are central for cognition and hallmark sleep in the rodent hippocampus. Recently, ripple-like activity was also observed in the human hippocampus and neocortex during wakefulness and sleep. However, ripple detection across brain states and cortical regions remains challenging. We demonstrate that putative ripples largely index noise originating from region-, state-, and demand-dependent modulation of cortical background activity. We establish the noise sensitivity for five common detection algorithms across three intracranial EEG studies during sleep and cognitive engagement. On average, 77% of awake ripples in the medial temporal lobe, including the hippocampus, reflect false positives within the 1/f

Indexed as

HippocampusAdultAlgorithmsCognitionElectroencephalographyFemaleHumansMaleNeocortexSleepTemporal LobeWakefulnessYoung Adult

Identifiers

PMID41547910
PMCPMC12820272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.