ArticleJournal of medical case reports2026
Behavioral abnormalities in older patients with chronic renal function decline following administration of compound paracetamol and amantadine hydrochloride capsules.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCompound paracetamol and amantadine hydrochloride capsules are commonly used over-the-counter medications at the primary care level. The primary component, amantadine, is excreted via the kidneys and poses a risk of accumulation in older patients, while chlorphenamine may increase the risk of delirium. This study examines the relationship between this medication and abnormal behavior by presenting case studies of two older patients and discussing clinical management strategies. CASE PRESENTATION: Case 1 involved a 78-year-old Chinese male with an estimated glomerular filtration rate (eGFR) of 87 mL/min/1.73 m
conclusionThe central toxicity of amantadine is significantly enhanced in older patients with renal insufficiency, and chlorphenamine may increase the risk of delirium. The risks associated with using this medication in older patients suffering from the common cold far outweigh the benefits, warranting cautious use in clinical practice; adverse reactions should be managed with prompt discontinuation of the medication and hydration to facilitate drug clearance. This study provides crucial warnings about medication safety in the older population.
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