Evidence map›Paper›PMID 41547853›Full record

ArticleJournal of neuroinflammation2026

Toxoplasma gondii drives myeloid immune cell recruitment to amyloid plaques in Alzheimer's model mice.

Katherine J Olivia Yanes, Christina T Bui, Julia Tomasello, Heba Morsy, Emilie Kim, Toan Lam, Kate Tsourmas, L Angel Ayala, Kim N Green, Matthew A Inlay and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katherine J Olivia YanesDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Christina T BuiDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Julia TomaselloDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Heba MorsyDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Emilie KimDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Toan LamDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Kate TsourmasDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
L Angel AyalaDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Kim N GreenDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Matthew A InlayDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Melissa B LodoenDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA. mlodoen@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Microglial immunity in Toxoplasmic encephalitisR21AI189465 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melissa Bruckner Lodoen · 2025 to 2026
$419k
Neuroinflammation during cerebral Toxoplasma gondii infectionR21AI155122 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LODOEN, MELISSA BRUCKNER · 2021 to 2022
$395k
NCI NIH HHS P30 CA062203NIAID NIH HHS R21 AI155122NIAID NIH HHS R21 AI189465NIGMS NIH HHS P50 GM076516
6 · The paper itself

Abstract

Infections in the central nervous system result in immune cell trafficking into the brain and microglial activation, which may influence Alzheimer's Disease neuropathology. Toxoplasma gondii infection induces a robust neuroimmune response and a reduction in amyloid plaques in the brains of Alzheimer's model mice. We investigated the myeloid cell response in the immediate vicinity of amyloid plaques in the brain by injecting 3-month-old 5xFAD mice with T. gondii or PBS as a control. T. gondii chronic infection (6 weeks) resulted in reduced amyloid plaque area, volume, and intensity in the cortex, and plaques with decreased circularity based on 6E10 and Thio-S staining. The brains of T. gondii-infected mice also had increased AIF1, AXL, and CLEC7A transcripts for disease-associated microglia (DAM), and elevated IBA1, MAC2, and CD68 phagolysosomal colocalization with amyloid, indicating myeloid cell activation around plaques. CD4 and CD8 T cells were also increased near amyloid and IBA1

Indexed as

Alzheimer DiseaseMyeloid CellsPlaque, AmyloidToxoplasmaToxoplasmosisAnimalsBrainDisease Models, AnimalFemaleMiceMice, TransgenicMicroglia5xFADAlzheimer’s diseaseAmyloid betaMicrogliaMonocytesMyeloid cellsT. gondii

Identifiers

PMID41547853
PMCPMC12896096

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.