ArticleBMC genomics2026
Isolation, identification and genomic analysis of Mycobacterium caprae strain SY-1 from Chinese sika deer (Cervus nippon).
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMycobacterium caprae, a member of the Mycobacterium tuberculosis complex, has been infrequently reported and studied in China. Recently, its emerging potential for cross-host transmission and drug resistance has raised public health concerns. This study reports the first isolation and whole-genome sequencing of M. caprae from Chinese sika deer (Cervus nippon), providing a detailed characterization of its genomic features.
resultsThe isolate SY-1 was identified as Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex (MTBC), based on morphological characteristics and PCR analysis. Whole-genome sequencing (WGS) revealed that isolate SY-1 possesses a genome of 4,346,248 bp with a GC content of 65.63%, encoding 4,162 predicted protein-coding sequences (CDSs). Furthermore, SY-1 harbors multiple virulence factors associated with pathogenicity and immune evasion, along with genes conferring resistance to isoniazid (katG) and ethambutol (embB, embC). Phylogenetic analysis demonstrated that SY-1 exhibits close relatedness to strains isolated from diverse host species. Phylogenetic analysis revealed that the SY-1 strain exhibits close phylogenetic relatedness to isolates derived from diverse host species. Furthermore, SY-1 clusters within a clade predominantly comprising isolates from Japan and China.
conclusionsThese findings provide the first evidence of M. caprae infection in Chinese sika deer. Strain SY-1 exhibits region-specific characteristics, demonstrating a high degree of host adaptability and cross-species transmission potential. This underscores its role as a potential zoonotic pathogen capable of facilitating the spread of tuberculosis and the dissemination of drug resistance, thereby posing a significant public health threat.
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