Evidence map›Paper›PMID 41547769›Full record

ArticleJournal of nanobiotechnology2026

Alkali-controlled one-pot synthesis of ultrasmall PEGylated polydopamine nanoparticles for diverse biological applications.

Yujie Tong, Jingjing Guo, Danfeng Wu, Bingjie Li, Xinyi Cai, Lin Yang, Jinbin Pan, Dianxun Fu, Cai Zhang, Dong Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yujie Tong *Department of Radiology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Jingjing Guo *Department of Radiology, Tianjin Huanhu Hospital, Tianjin, 300350, China.
Danfeng Wu *Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, Tianjin, 300070, China.
Bingjie LiDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Xinyi CaiSchool of Medical Imaging, School of Medical Technology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.
Lin YangDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Jinbin PanDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Dianxun FuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Cai ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre of Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, 300060, China.
Dong LiDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China. dr_lidong@tmu.edu.cn.
Shao-Kai SunSchool of Medical Imaging, School of Medical Technology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China. shaokaisun@tmu.edu.cn.
Jiaojiao YuSchool of Medical Imaging, School of Medical Technology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China. yujiaojiao91@tmu.edu.cn.

Funding

National Natural Science Foundation of China 82202830, 82271937, 82471927Natural Science Foundation of Tianjin City 22JCZDJC00500, 23JCQNJC00620, 24ZXGQSY00100Scientific Research Project of the Tianjin Municipal Education Commission 2023ZD020Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-008CTianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK001ATianjin Science and technology planning project 21ZXJBSY00120
6 · The paper itself

Abstract

backgroundPolydopamine nanoparticles (PDA NPs) hold considerable significance in biomedical field due to their diverse multifunctionality, including efficient metal ion chelation, intrinsic antioxidant activity, and robust photothermal properties. Especially, ultrasmall PDA NPs can evade rapid liver and spleen accumulation, enabling multi-organ distribution and wide biological applications. However, current methods for synthesizing ultrasmall PDA NPs face the bottleneck of complex synthesis processes.

methodsWe showed an alkali-controlled one-pot synthesis of ultrasmall PEGylated PDA (UPPDA) NPs. Upon Mn

resultsPPMn NPs enable precise diagnosis of glioma, carotid artery stenosis, and acute kidney injury through MRI. Additionally, UPPDA and PPMn NPs exhibit outstanding antioxidant properties and demonstrate effective photothermal ablation capabilities at the cellular level.

conclusionsThe proposed UPPDA NPs provide a universal platform for the diagnosis and treatment of various diseases.

Indexed as

AlkaliesIndolesNanoparticlesPolyethylene GlycolsPolymersAnimalsAntioxidantsCell Line, TumorContrast MediaGliomaHumansMagnetic Resonance ImagingMicePhotothermal TherapyAlkaliesAntioxidantsContrast MediaIndolespolydopaminePolyethylene GlycolsPolymersAntioxidant treatmentMagnetic resonance imagingPhotothermal therapyUltrasmall polydopamine

Identifiers

PMID41547769
PMCPMC12930558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.