ArticleBMC microbiology2026
Influence of polyunsaturated fatty acids on Aeromonas hydrophila: sole carbon utilization, incorporation into membrane phospholipids, potentiation of cyclic lipopeptide activity, and other phenotypic impacts.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Aeromonas hydrophila is an adaptable and dangerous member of a genus capable of colonizing and infecting many hosts. Inhabitants of various aquatic environments, A. hydrophila can adversely affect aquaculture and cause human disease. The aim of this study was to determine the extent of polyunsaturated fatty acid (PUFA) handling in A. hydrophila with regard to incorporation into membrane phospholipids and effects on permeability, growth, antimicrobial resistance, biofilm formation, and swimming motility. Extracted phospholipids from PUFA-supplemented cultures were examined for lipid modification using both thin-layer chromatography and ultra performance liquid chromatography-mass spectrometry, demonstrating partial incorporation of all tested PUFAs. Phenotypic characteristics were evaluated using assays that tested for biofilm formation, membrane permeability, swimming motility, and antibiotic susceptibility. Temperature-dependent effects on biofilm formation and swimming motility were observed, and exposure to certain PUFAs resulted in significant (P < 0.005) increases to membrane permeability using a hydrophobic dye uptake assay. Importantly, several PUFAs caused substantial (up to 16-fold) lowering of minimum inhibitory concentrations (MICs) against the membrane-active cyclic peptides polymyxin B and colistin. These responses to exogenous PUFAs may predict cellular signaling capabilities that aid multi-host pathogenic bacteria in their diverse environmental interactions.
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