ArticleEJNMMI radiopharmacy and chemistry2026
Quality control of actinium-225 and
Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Inline gamma spectroscopy and liquid scintillation HPLC reveal daughters inEJNMMI radiopharmacy and chemistry · 2026Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundActinium-225 radiopharmaceuticals have drawn great interest in cancer therapy due to their tumor-specific delivery of cytotoxic alpha-particles. Quality control (QC) is critical for these potent agents and there is currently no consensus for best practice of actinium-225 QC. Detection of actinium-225 (T
resultsThe plastic silicon scanner resulted in RCY% differences between 30 min and > 5 h evaluations, whereas the gas-filled proportional counter, when varying voltages, showed minor differences. Similarly, HPGe-TLC demonstrated equivalent RCY% between both equilibria. The NaI(Tl), LSC- TLC, and HPLC-gamma counting significantly underestimated RCY% or RCP% at 30 min. Considering gamma well counting LOQ and
conclusionFive instruments have been tested for their linearity, sensitivity, accuracy and specificity to actinium-225 quantification using francium-221 and bismuth-213 equilibria. Francium-221 equilibrium was deemed acceptable for TLC RCY% using HPGe and gas-filled proportional counter. Gamma well counting, LSC, and plastic silicon detector required bismuth-213 equilibrium for accurate RCY%. Low content free actinium-225 impurity was accurately reported for all methods except for the silicon detector. Overall, this investigation sheds light on the appropriate analytical methods for
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