Evidence map›Paper›PMID 41547614›Full record

ArticleBritish journal of anaesthesia2026

Causal evidence linking chronic pain genetics to late-onset asthma via the nervous system.

Goodarz Kolifarhood, Marc Parisien, Matt Fillingim, Charlise Chen, Yiran Chen, Nikolay Dimitrov, Maha Zidan, Lovéni Hanumunthadu, Peter H Her, Sahir Bhatnagar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Goodarz KolifarhoodDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Marc ParisienDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Matt FillingimFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Charlise ChenDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Yiran ChenDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada; Institut de recherches cliniques de Montréal (IRCM), Montreal, QC, Canada.
Nikolay DimitrovDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Maha ZidanFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Lovéni HanumunthaduFaculty of Engineering, McGill University, Montreal, QC, Canada.
Peter H HerDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.
Sahir BhatnagarDepartment of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada.
Luda DiatchenkoDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Audrey V GrantDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill University Montreal, QC, Canada; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. Electronic address: audrey.grant@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic pain and asthma are associated, but the direction and basis of their genetic and biological relationship remain unclear.

methodsWe conducted genome-wide association studies (GWAS), multi-trait analysis of GWAS (MTAG), polygenic risk score (PRS) prediction, bivariate causal modelling, and Mendelian randomisation (MR) across nine chronic pain traits and three asthma age-of-onset strata (<18, 18-40, and >40 yr for childhood-, adult-, and late-onset asthma, respectively) in 456 958 UK Biobank and 25 275 Canadian Longitudinal Study on Aging participants of European descent. We analysed shared and distinct genetic architecture using gene-, pathway-, tissue-, and cell-type-based enrichment analyses.

resultsMultisite chronic pain (MCP) showed the strongest and most consistent genetic overlap with asthma, with genetic correlation increasing from childhood (r

conclusionsThese findings reveal neurological function linking chronic pain to late-onset asthma, distinct from childhood asthma, and highlight a CNS contribution to asthma emerging later in life.

Indexed as

AsthmaChronic PainAdolescentAdultAgedAge of OnsetCanadaChildFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansLongitudinal StudiesMaleMendelian Randomization Analysisageingasthmachronic paingeneticsgenome-wide associationgenomicslongitudinalpolygenic risk score

Identifiers

PMID41547614
PMCPMC12975362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.