Evidence map›Paper›PMID 41547459›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Confounders, diagnostic accuracy, and reproducibility in cardiovascular magnetic resonance-feature tracking-derived left atrial strain: A Berlin Research Network for cardiovascular magnetic resonance multi-software, multi-site comparison.

Leo Dyke Krüger, Leonhard Grassow, Jan Gröschel, Johanna Kuhnt, Edyta Blaszczyk, Maximilian Müller, Ralf Felix Trauzeddel, Teodora Chitiboi, Jeanette Schulz-Menger, Maximilian Fenski

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leo Dyke KrügerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Leonhard GrassowCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Jan GröschelCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité - Department of Cardiology, Angiology and Intensive Care Medicine, Berlin, Germany.
Johanna KuhntCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Edyta BlaszczykCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Maximilian MüllerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Ralf Felix TrauzeddelCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany; Department of Anesthesiology and Intensive Care Medicine, Charité Campus Benjamin Franklin, Berlin, Germany.
Teodora ChitiboiSiemens Healthineers AG, Hamburg, Germany.
Jeanette Schulz-MengerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany; HELIOS Clinics Berlin Buch, Department for Cardiology and Nephrology, Berlin, Germany. Electronic address: jeanette.schulz-menger@charite.de.
Maximilian FenskiCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany; HELIOS Clinics Berlin Buch, Department for Cardiology and Nephrology, Berlin, Germany; Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular magnetic resonance-feature tracking (CMR-FT) derived left atrial global longitudinal strain (LA-GLS) has prognostic relevance, even in the early stages of cardiovascular diseases. Identifying technical and subject-related confounders is essential for ensuring comparability across sites and for reliably distinguishing healthy from pathological conditions. This study aimed to evaluate the influence of post-processing software and subject-related factors on CMR-FT-derived LA-GLS, diagnostic accuracy, and to evaluate inter-site reproducibility.

methodsThis study included 149 healthy individuals and 40 patients with atrial fibrillation (AF; 19 persistent, 21 paroxysmal) from a single site. A subgroup of 18 traveling volunteers underwent CMR at four different sites. All participants underwent CMR in sinus rhythm. LA-GLS was assessed using three post-processing software packages (CVI42, TrufiStrain Research Prototype, Medis). Mixed models with repeated measures were applied to evaluate the effect of software, site, and subject-related factors on LA-GLS components. ROC curve analysis was used to assess diagnostic accuracy across software in distinguishing healthy controls from AF patients.

resultsAll GLS components differed across post-processing software (p<.001). Reservoir and contractile GLS were lowest in CVI42 (23.9% ± 3.3%, 9.9% ± 2.2%), followed by TrufiStrain (27.4% ± 6.3%, 15.0% ± 4.8%) and Medis (45.4% ± 9.7%, 20.3% ± 5.7%). Conduit GLS was lowest in TrufiStrain (12.4% ± 4.8%), followed by CVI42 (16.3% ± 4.5%) and Medis (25.1% ± 8.2%). Among traveling volunteers, LA-GLS values were consistent across sites when the same software was used. Across all software, reservoir GLS negatively correlated with age. Diagnostic accuracy was comparable across software packages (AUC for reservoir strain: CVI: 0.81 [0.69-0.90], TrufiStrain 0.76 [0.64-0.88], Medis: 0.84 [0.72-0.94]).

conclusionPost-processing software is a significant confounder in CMR-FT-based LA-GLS analysis and age substantially influences LA-GLS. LA-GLS demonstrates excellent inter-site reproducibility when analyzed with the same software and offers comparable diagnostic accuracy across platforms.

Indexed as

Atrial FibrillationAtrial Function, LeftGlobal Longitudinal StrainHeart AtriaImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineSoftwareAdultAgedBiomechanical PhenomenaCase-Control StudiesFemaleHumansMaleMiddle AgedObserver VariationDeformationInfluencing factorsNormal rangesSoftware

Identifiers

PMID41547459
PMCPMC13196062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.