Evidence map›Paper›PMID 41547316›Full record

ArticleEnvironment international2026

Fine and ultrafine particulate matter components and autism spectrum disorder (ASD).

Amanda J Goodrich, Deborah H Bennett, Michael J Kleeman, Daniel J Tancredi, Yunin J Ludeña, Irva Hertz-Picciotto, Rebecca J Schmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda J GoodrichDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address: ajgoodrich@health.ucdavis.edu.
Deborah H BennettDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Michael J KleemanDepartment of Civil and Environmental Engineering, University of California Davis, Sacramento, CA, USA.
Daniel J TancrediDepartment of Pediatrics, University of California Davis, Sacramento, CA, USA.
Yunin J LudeñaDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; MIND Institute, University of California Davis, Sacramento, CA, USA.
Irva Hertz-PicciottoDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; MIND Institute, University of California Davis, Sacramento, CA, USA.
Rebecca J SchmidtDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; MIND Institute, University of California Davis, Sacramento, CA, USA.

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ameer Taha · 2015 to 2026
$26.0M
THE CHARGE STUDY: CHILDHOOD AUTISM RISKS FROM GENETICS AND THE ENVIRONMENT - ADMINISTRATIVE SUPPLEMENTR01ES015359 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2007 to 2019
$13.8M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
The CHARGE Study Phase II: A Multifactorial Approach to Autism EtiologyR01ES031701 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BENNETT, DEBORAH HALL, HERTZ-PICCIOTTO, IRVA · 2020 to 2025
$8.3M
Exploring Interactions between Folate and Environmental Risk Factors for AutismR21ES021330 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2012 to 2014
$481k
NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES015359NIEHS NIH HHS R01 ES031701NIEHS NIH HHS R21 ES021330
6 · The paper itself

Abstract

backgroundParticulate matter (PM) composition varies by source components and size. While studies show prenatal and early life exposure to total PM

objectivesWe investigated associations between prenatal and early life exposure to size-resolved PM components and ASD in the CHARGE case-control study.

methodsWe analyzed 1,281 children (751 ASD, 530 typically developing) from the CHARGE study (enrolled 2003-2020). Daily PM

resultsFirst-year PM DISCUSSION: Our findings suggest that exposure to specific PM components during early life, especially in the ultrafine fraction, contribute to ASD risk, with less consistent evidence for prenatal exposures, underscoring the importance of particle composition and exposure timing.

Indexed as

Air PollutantsAutism Spectrum DisorderEnvironmental ExposureParticulate MatterCase-Control StudiesChildChild, PreschoolFemaleHumansMaleParticle SizePregnancyPrenatal Exposure Delayed EffectsAir PollutantsParticulate MatterAir PollutionAutismEarly lifeFine particulate (PM(2.5))PregnancyUltrafine particulate (PM(0.1))

Identifiers

PMID41547316
PMCPMC13397011

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.