Evidence map›Paper›PMID 41547159›Full record

ArticleJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2026

ZIP3 is essential for the encephalitogenic function of pTh17 cells by regulating intracellular zinc levels.

Dominik Drmić, Liwei Wang, Lucile Noyer, Li Zhong, Stefan Feske

Abstract read
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In one paragraph

Article in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dominik DrmićDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Liwei WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Lucile NoyerDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Li ZhongDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Stefan FeskeDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: stefan.feske@nyulangone.org.

Funding

Regulation of encephalitogenic T cells by CRAC channelsR01AI137004 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2018 to 2022
$2.4M
ATP1B3: novel regulator of T cell-mediated immunityR01AI180128 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STEFAN FESKE · 2024 to 2026
$1.9M
NIAID NIH HHS R01 AI137004NIAID NIH HHS R01 AI180128
6 · The paper itself

Abstract

backgroundZinc (Zn

methodsWe used a forward genomic screen to identify Zn

resultsUsing a shRNA screen in myelin-specific pTh17 cells in vivo, we found that ZIP3 is required for their expansion in the CNS of mice with EAE. When ectopically expressed, ZIP3 was located predominantly in the Golgi apparatus. Deletion of Slc39a3 resulted in decreased cytosolic Zn

conclusionsZIP3 is essential for the encephalitogenic function of pTh17 cells and promoting EAE, likely by regulating cytosolic Zn

Indexed as

Cation Transport ProteinsEncephalomyelitis, Autoimmune, ExperimentalTh17 CellsZincAnimalsFemaleMiceMice, Inbred C57BLCation Transport ProteinsZincAutoimmunityEAESLC39A3Th17 cellsZincZIP3

Identifiers

PMID41547159
PMCPMC13251312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.