Evidence map›Paper›PMID 41546866›Full record

ArticleCell reports2026

Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.

Ricardo Rivero, Vaneza Tique-Salleg, Daniel Echeverri-De la Hoz, Lambodhar Damodaran, Daniela Paternina, Mauricio Santos-Vega, Daniela Torres-Hernández, Diana Davalos, Eduardo López-Medina, Mallery I Breban and 5 more

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Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ricardo RiveroPaul G. Allen School for Global Health, Washington State University, Pullman, WA 99164, USA; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia. Electronic address: ricardo.rivero@wsu.edu.
Vaneza Tique-SallegInstituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia; Hospital San Jeronimo, Montería 230001, Colombia.
Daniel Echeverri-De la HozInstituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia; Universidad de Santander, Facultad de Ciencias Médicas y de la Salud, Programa de Bacteriología y Laboratorio Clínico, Valledupar, Colombia.
Lambodhar DamodaranDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniela PaterninaInstituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia.
Mauricio Santos-VegaGrupo de Biologia Matematica y Computacional (BIOMAC), Universidad de los Andes, Bogotá D.C. 10587, Colombia.
Daniela Torres-HernándezCentro de Estudios en Infectologia Pediatrica CEIP, Cali, Colombia.
Diana DavalosCentro de Estudios en Infectologia Pediatrica CEIP, Cali, Colombia.
Eduardo López-MedinaCentro de Estudios en Infectologia Pediatrica CEIP, Cali, Colombia.
Mallery I BrebanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 610101, USA.
German ArrietaInstituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia; Clínica Salud Social, Sincelejo, Sucre, Colombia.
Jorge MirandaInstituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia.
Verity HillDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 610101, USA.
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 610101, USA.
Salim MattarInstituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia. Electronic address: smattar@correo.unicordoba.edu.co.

Funding

Enhancing dengue virus genomic surveillance to uncover circulating genetic diversityDP2AI176740 · NIAID · YALE UNIVERSITY · PI GRUBAUGH, NATHAN DALE · 2022 to 2025
$2.5M
NIAID NIH HHS DP2 AI176740
6 · The paper itself

Abstract

Dengue fever, a major mosquito-borne viral disease, is transmitted by Aedes mosquitoes and poses a significant global health burden. Despite extensive research, the spatiotemporal dynamics of dengue virus (DENV) lineages in Colombia remain understudied. Here, we analyze 11,443 complete genome sequences from Colombia and the Americas to map the genomic epidemiology of DENV-2 and DENV-3. Phylogeographic reconstruction revealed multiple independent introductions and exportations of the DENV-2 II and III lineages, as well as the DENV-3 lineage III_C.2, underscoring Colombia's critical role as both a source and a sink of viral traffic within the Americas. Antigenic profiling demonstrated distinct clustering of emergent lineages in antigenic space, consistent with immune-escape-driven turnover. These results highlight the necessity of sustained, high-resolution genomic surveillance to guide targeted public health interventions and mitigate dengue transmission across the region.

Indexed as

DengueDengue VirusGenome, ViralAedesAnimalsColombiaGenomicsHumansPhylogenyPhylogeographyantigenic escapearbovirusesCP: microbiologygenomic epidemiologyphylogeographypublic healthvector-borne disease

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.