Evidence map›Paper›PMID 41546839›Full record

ArticleCancer causes & control : CCC2026

Impact of psychiatric disorders on treatment adherence and overall survival in patients with Hodgkin lymphoma: a retrospective cohort study.

Gerardo Santiago-Jiménez, Alonso Hernández-Company, Josheline G Ramírez-Jaramillo, Lena G Simental-Legarda, Efreen H Montaño-Figueroa, Christian O Ramos-Peñafiel, Humberto B Castellanos-Sinco, Emmanuel Martínez-Moreno, Juan F Zazueta-Pozos, Gilberto I Barranco-Lampón and 1 more

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Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Gerardo Santiago-JiménezHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico. santticpk@gmail.com.
Alonso Hernández-CompanyHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico. alonso.hernandez.company@gmail.com.
Josheline G Ramírez-JaramilloHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Lena G Simental-LegardaHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Efreen H Montaño-FigueroaHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Christian O Ramos-PeñafielHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Humberto B Castellanos-SincoHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Emmanuel Martínez-MorenoHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Juan F Zazueta-PozosHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Gilberto I Barranco-LampónHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.
Carlos Martínez-MurilloHospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychiatric comorbidities are common in patients with Hodgkin lymphoma (HL) and may influence treatment adherence and survival outcomes. This study aimed to evaluate the impact of psychiatric disorders on overall survival and treatment adherence in HL patients.

methodsA retrospective cohort study was conducted including 139 HL patients treated at the General Hospital of Mexico "Dr Eduardo Liceaga." Clinical, demographic, and psychiatric data were collected. Overall survival was analyzed using Kaplan-Meier curves and Cox proportional hazards models adjusted for Ann Arbor stage, treatment adherence, and psychiatric disorders. Treatment adherence was assessed, and its association with survival was explored using time-varying hazard ratios.

findingsAmong 139 patients, those with psychiatric disorders exhibited significantly worse overall survival (HR 6.80, 95% CI 1.32-34.95, p = 0.022). Adherence to treatment was independently associated with improved survival (HR 0.05, 95% CI 0.02-0.16, p < 0.001). Time-varying analysis showed the highest hazard ratio for psychiatric disorders during the early follow-up period.

conclusionPsychiatric disorders are independently associated with poorer overall survival in patients with Hodgkin lymphoma, partly mediated by reduced treatment adherence. Early recognition and integrated psychosocial interventions may improve treatment continuity and survival outcomes.

Indexed as

Hodgkin DiseaseMental DisordersTreatment Adherence and ComplianceAdolescentAdultFemaleHumansMaleMexicoMiddle AgedRetrospective StudiesYoung AdultHematologic malignanciesHodgkin lymphomaOverall survivalPsychiatric disordersTreatment adherence

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.