Evidence map›Paper›PMID 41546748›Full record

ArticleBulletin of experimental biology and medicine2025

Comparative Characteristics of Morphometric Changes in the Brain Tissue Caused by Prenatal Alcohol Exposure and Hypoxia.

S N Shumilova, A V Solonsky, A V Potapov, S V Logvinov, N A Bokhan, A I Mandel, A Sh Makhmutkhodzhaev, E Y Varakuta, L R Mustafina, A A Zhdankina and 4 more

Abstract readComparative Study
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

S N ShumilovaMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. sofashumilova97@gmail.com.
A V SolonskyMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A V PotapovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
S V LogvinovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
N A BokhanMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A I MandelMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A Sh MakhmutkhodzhaevSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
E Y VarakutaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
L R MustafinaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
A A ZhdankinaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
A V GerasimovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
V P KostyuchenkoSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
K Y MaksimovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
E Y BulatskayaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to current knowledge, hypoxia is a key mechanism mediating the detrimental effects of prenatal alcohol exposure on the nervous tissue. However, comparative analysis of these interrelated conditions has only been partially addressed. We conducted a morphometric analysis of fetal brain tissue affected by chronic alcohol exposure and hypoxia. A decrease in the specific area of neuroblasts, glioblasts, and microvascular elements was found. Hypoxia promoted enlargement of neuroblasts and their differentiation into immature neurons, whereas alcohol exposure led only to a decrease in their number. In the brain subjected to hypoxia, glioblasts were characterized by size variability with a general trend toward reduction, while alcohol had no significant effect on their size. Both experimental groups showed a decline in vascular density.

Indexed as

BrainEthanolHypoxiaPrenatal Exposure Delayed EffectsAnimalsCell DifferentiationFemaleNeural Stem CellsNeuronsPregnancyRatsEthanolalcoholglioblastshypoxiamicrovasculatureneuroblasts

Identifiers

PMID41546748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.