Evidence map›Paper›PMID 41546747›Full record

ArticleBulletin of experimental biology and medicine2025

Dynamics of Morphological Changes of Axons in the Lateral (Deiters) Vestibular Nuclei in Mice after Long-Term Stimulation.

I B Mikheeva, N S Zhuikova, L L Pavlik, V I Arkhipov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

I B MikheevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. mikheirina@yandex.ru.
N S ZhuikovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
L L PavlikInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
V I ArkhipovInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mice were subjected to vestibular stimulation (rotation at 80 rpm for 8 h) and behavioral disturbances and morphological changes in the Deiters' vestibular nuclei were studied 1 h and 2, 5, and 7 days after stimulation. Horizontal and vertical motor activity decreased after long-term vestibular stimulation and recovered after 1 day. Short- and long-term disturbances in the morphology of Deiters' neurons and neuropil were detected. Disturbances in the structure of neurons were no longer detected 2 days after stimulation, while disturbances in myelinated axons in the neuropil persisted for up to 7 days. These disturbances manifested by abnormal water distribution and pronounced damage to the myelin sheath. It is assumed that long-term edema of myelinated axons is a target for therapeutic intervention in diseases associated with axonal demyelination.

Indexed as

AxonsVestibular NucleiVestibular Nucleus, LateralAnimalsMaleMiceMotor ActivityMyelin SheathNeuronsRotationaxonal demyelinationDeiters’ vestibular nucleusmiceultrastructurevestibular stimulation

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.