ArticleBulletin of experimental biology and medicine2025
Dynamics of Morphological Changes of Axons in the Lateral (Deiters) Vestibular Nuclei in Mice after Long-Term Stimulation.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mice were subjected to vestibular stimulation (rotation at 80 rpm for 8 h) and behavioral disturbances and morphological changes in the Deiters' vestibular nuclei were studied 1 h and 2, 5, and 7 days after stimulation. Horizontal and vertical motor activity decreased after long-term vestibular stimulation and recovered after 1 day. Short- and long-term disturbances in the morphology of Deiters' neurons and neuropil were detected. Disturbances in the structure of neurons were no longer detected 2 days after stimulation, while disturbances in myelinated axons in the neuropil persisted for up to 7 days. These disturbances manifested by abnormal water distribution and pronounced damage to the myelin sheath. It is assumed that long-term edema of myelinated axons is a target for therapeutic intervention in diseases associated with axonal demyelination.
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