Evidence map›Paper›PMID 41546746›Full record

ArticleBulletin of experimental biology and medicine2025

Peculiarities of Reparative Osteogenesis in Lower Jaw Defects in Rats with Experimental Metabolic Syndrome.

M V Makarova, Yu D Lyashev, A V Solin, V S Serikov, S A Klevtsov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M V MakarovaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. marina-golovina@inbox.ru.
Yu D LyashevKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
A V SolinBelgorod State National Research University, Belgorod, Russia.
V S SerikovKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
S A KlevtsovKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reparative osteogenesis was studied in rats with metabolic syndrome simulated by a high-fat and high-carbohydrate diet for 12 weeks. In rats with and without metabolic syndrome, a hole with a diameter of 3 mm was drilled in the right molar region of the lower jaw. There were no differences in lower jaw structure in rats with metabolic syndrome in comparison with intact animals. The results of the bone defect regeneration confirm delayed reparative osteogenesis, manifested as a decrease in the relative area of newly formed bone tissue, the relative area of trabeculae, the thickness of trabeculae, number of osteocytes, osteoblasts, and osteoclasts, and an increase in the relative area of fibrous connective tissue on days 7, 14, 21, and 28 after surgery on the lower jaw in rats with metabolic syndrome.

Indexed as

Bone RegenerationMandibleMetabolic SyndromeOsteogenesisAnimalsDiet, High-FatDisease Models, AnimalMaleOsteoblastsOsteoclastsOsteocytesRatsRats, Wistarbone defectlower jawmetabolic syndromereparative osteogenesis

Identifiers

PMID41546746

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.