Evidence map›Paper›PMID 41546744›Full record

ReviewActa neurochirurgica2026

A concise history of skull base surgery: what is its contribution to neurosurgery?

M Necmettin Pamir, Tiit Illimar Mathiesen, Zeynep Hüseyinoğlu, Baran Bozkurt, Koray Özduman

Abstract readHistorical ArticleReview
In one paragraph

Review in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M Necmettin PamirSchool of Medicine, Department of Neurosurgery, Acıbadem University, Istanbul, Turkey.
Tiit Illimar MathiesenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Zeynep HüseyinoğluSchool of Medicine, Department of Neurosurgery, Acıbadem University, Istanbul, Turkey.
Baran BozkurtSchool of Medicine, Department of Neurosurgery, Acıbadem University, Istanbul, Turkey.
Koray ÖzdumanSchool of Medicine, Department of Neurosurgery, Acıbadem University, Istanbul, Turkey. koray.ozduman@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkull base neurosurgery (SBNS) emerged as a specialized branch of microneurosurgery as it addressed the challenges posed by intricate skull base anatomy. Initially developed through close collaboration with otolaryngologists, SBNS expanded in the 1990s and has undergone substantial advancements over the following decades. In this review, we analyze whether SBNS evolved as an organic development within neurosurgery or an external innovation, and we review key historical literature to support of either hypothesis.

methodsThis is a synthetic, narrative historical review. An initial Pubmed review was performed with combination of keywords of "skull base neurosurgery", "skull base surgery", "neuroanatomy", "microsurgical anatomy" and" neurosurgery complications". Resulting database was restructured based on peer to peer, semi-structured interviews of two senior skull base neurosurgeons, with over 25 skull base neurosurgeons that were active 1970s-1990s. Emerging themes formed the framework for the analysis.

resultsThe evolution of SBNS was organic. It could be categorized into four distinct phases: Initially, Early attempts preceding the systematic application of SBNS techniques, subsequently the birth phase coincided with the widespread adoption of microneurosurgery and the establishment of dedicated societies and international meetings. During the popularization phase, advances in microneuroanatomy and novel approaches enhanced outcomes. Finally, the Maturation phase brought refined surgical approaches, the reevaluation of surgical indications, and the integration of stereotactic radiosurgery and endoscopic skull base surgery as well as international collaboration and teaching activities. DISCUSSION: SBNS emerged within neurosurgery as a means to address challenging skull base pathologies and to enable surgical access through the skull-base. Its development was driven by collaboration with otolaryngology, alongside technological innovations such as the operating microscope, power drills, endoscopy, and stereotactic radiosurgery. These innovations facilitated the creation of novel surgical approaches, which were later refined through advances in neuroanatomical knowledge and improved understanding of pathology. Over time, SBNS were integrated into general neurosurgical practice and training curricula, allowing wide implementation and continued evolution in many directions.

Indexed as

MicrosurgeryNeurosurgeryNeurosurgical ProceduresSkull BaseHistory, 20th CenturyHistory, 21st CenturyHumansMicroneuroanatomyMicroneurosurgerySkull-base

Identifiers

PMID41546744
PMCPMC12816123

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.