ArticleIrish journal of medical science2026
Age-related effects of high protein diet on rat liver and kidney.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backroundWhile low-carbohydrate/high-protein diets are common for rapid weight loss, their controversial side effects warrant investigation.
aimsThis study aimed to examine age- and duration-dependent effects of high-protein diets on the liver and kidneys of adult (6 months) and elderly (18 months) rats.
methodsThirty-two male Wistar albino rats were divided into four groups: Adult Standard, Adult High-Protein, Elderly Standard, and Elderly High-Protein. After one month, we collected kidney and liver samples for histological analysis and biochemical assessment of MDA and GSH levels.
resultsHigh-protein diets severely affected the kidneys of both adult and elderly rats. The livers also exhibited moderate degenerative changes. We found a significant increase in MDA levels, indicating lipid peroxidation. Additionally, hepatic and renal GSH levels significantly increased in elderly rats on a high-protein diet, suggesting a metabolic response to oxidative stress.
conclusionOur findings suggest that high-protein diets should be applied very cautiously, especially in elderly individuals and those with existing kidney disorders.
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