Trial reportLangenbeck's archives of surgery2026
Individualized vs. standard control of intraoperative blood pressure on serum creatinine profile and release of microRNA-21-5p after major gastrointestinal surgery in older patients with hypertension: a randomized controlled trial.
Trial report in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIntraoperative hypotension is associated with a postoperative decline in renal function, and the effect of personalized blood pressure control on renal function remains unknown. The aim of this study was to investigate the effects of individualized intraoperative blood pressure management on renal function and serum microRNA-21-5p levels in older patients with hypertension after major gastrointestinal surgery.
methodsA total of 220 patients scheduled for elective major gastrointestinal surgery were randomly divided into two groups: conventional blood pressure management (Group C) and individualized blood pressure management (Group S), with 110 patients in each group. In Group S, blood pressure was controlled within ± 10% of baseline systolic blood pressure or ± 20% of baseline mean arterial pressure. Moderately open fluid management strategies were adopted in both groups. Blood samples were collected from all patients before and after surgery to measure creatinine and microRNA-21-5p levels.
resultsThe creatinine level was significantly lower in Group S than in Group C 7 days after surgery (P < 0.05), and the reduction in creatinine levels in the week following surgery was also significantly greater in Group S than in Group C (P < 0.05).
conclusionIntraoperative individualized blood pressure management could reduce the release of microRNA-21-5p related to renal injury and attenuate the increase in postoperative creatinine levels in older patients with hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.