Evidence map›Paper›PMID 41546604›Full record

ArticleVeterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association2026

Defining Variations in the Size of Normal Pituitary Glands and Pituitary Macrotumors Based on Canine Skull Morphology.

Hannah V Pham, Kelsey D Brust, Jessica A Lawrence, Matthias Rosseel, Michael S Kent

Abstract read
In one paragraph

Article in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Defining Variations in the Size of Normal Pituitary Glands and Pituitary Macrotumors Based on Canine Skull Morphology.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hannah V PhamVeterinary Medical Teaching Hospital, University of California Davis School of Veterinary Medicine, Davis, California, USA.
Kelsey D BrustDepartment of Veterinary Surgery and Radiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.ORCID https://orcid.org/0000-0001-9726-8879
Jessica A LawrenceDepartment of Veterinary Surgery and Radiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.ORCID https://orcid.org/0000-0002-8315-1909
Matthias RosseelDepartment of Veterinary Surgery and Radiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.
Michael S KentDepartment of Veterinary Surgery and Radiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.ORCID https://orcid.org/0000-0002-7703-7720

Funding

Students Training in Advanced Research (STAR) ProgramT35OD010956 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DANIKA L BANNASCH · 2012 to 2026
$1.6M
National Science FoundationNIH HHS T35 OD010956UC Davis Center for Companion Animal Health and the School of Veterinary Medicine Students Training in Advanced Research
6 · The paper itself

Abstract

Computed tomography (CT) is a common imaging modality used to evaluate for a pituitary macrotumor in dogs. However, a standard definition of a pituitary macrotumor based on imaging characteristics has not yet been established. The human definition of a pituitary mass that measures >1 cm in diameter has previously been adopted for dogs but fails to account for variability in size, breed, and skull conformation. We hypothesized that normal pituitary gland size and macrotumor size vary by skull morphology. We also hypothesized that canine pituitary macrotumors may be smaller than 1 cm. In this retrospective, case-control analytical study, contrast CT scans from 89 dogs with imaging-diagnosed pituitary macrotumors and 89 dogs with normal pituitary glands were compared. The height, length, width, and volume of the pituitary gland, sella turcica, and brain were measured along with the brain area at the level of the pituitary gland. Of the pituitary macrotumors, 21.3% (19/89) were smaller than 1 cm in height. Data support that a pituitary gland height >0.60 cm or a pituitary volume of 0.17 cm

Indexed as

Dog DiseasesPituitary GlandPituitary NeoplasmsSkullAnimalsCase-Control StudiesDogsFemaleMaleRetrospective StudiesTomography, X-Ray ComputedcanineCTmacroadenomamacrotumorpituitary

Identifiers

PMID41546604
PMCPMC12811897

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.