Evidence map›Paper›PMID 41546421›Full record

ReviewAngewandte Chemie (International ed. in English)2026

Empowering Precision C-H Functionalization: Advances in Peroxygenase Engineering.

Shuaiqi Meng, Zhongyu Li, Yuncheng Du, Xiao Cheng, Binbin Nian, Siyu Fu, Xiaofei Song, Haiyang Cui

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuaiqi Meng *State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, 210097, China.
Zhongyu Li *Institute of Biotechnology, RWTH Aachen University, Aachen, 52074, Germany.
Yuncheng Du *CSPC Pharmaceutical Group Limited, Shijiazhuang, 050035, China.
Xiao ChengState Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, 210097, China.
Binbin NianState Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, China.
Siyu FuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Xiaofei SongCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Haiyang CuiState Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, 210097, China.ORCID 0000-0001-8360-0447

Funding

Basic Research Program of Jiangsu BK20253050Coal-Major Project 2025ZD1701600Jiangsu Basic Research Center for Synthetic Biology BK20233003Jiangsu Province "Entrepreneurship and Innovation Plan" Education Fund 164080H00250Ministry of Education Key Laboratory of NSLSCSNational Natural Science Foundation of China 22478199Priority Academic Program Development of Jiangsu Higher Education Institutions 164320H1865Research Start-up Fund of Nanjing Normal University 184080H201B94State Key Laboratory of Microbial Technology Open Projects M2025-17
6 · The paper itself

Abstract

Selective C-H functionalization remains a central challenge in modern synthesis as it enables direct diversification of molecular scaffolds without pre-functionalization. Peroxygenases, including both unspecific peroxygenases and P450 peroxygenases, offer a biocatalytic solution to this challenge, catalyzing oxyfunctionalization reactions in aqueous media under mild conditions with hydrogen peroxide (H

Indexed as

CarbonMixed Function OxygenasesProtein EngineeringBiocatalysisCytochrome P-450 Enzyme SystemHydrogen PeroxideCarbonCytochrome P-450 Enzyme SystemHydrogen PeroxideMixed Function OxygenasesperoxygenaseC–H functionalizationCytochrome P450PeroxygenaseProtein engineering

Identifiers

PMID41546421
PMCPMC13411511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.