ArticleAdvanced materials (Deerfield Beach, Fla.)2026
DNA Origami-Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Programmable DNA Assemblies Reconstitute Supramolecular Protein Function.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Chirality refers to handedness as left- or right-handed form of a molecule or molecular construct by synthesis or self-assembly. In biology, chirality plays critical roles in determining the structures and functions of biomolecules such as proteins. In this study, we demonstrated that structural chirality generated by patterning multiple cell surface protein biomarker-binding aptamers on a tubular-shaped DNA origami ("DNA tube") can realize differentness in cellular interaction, nanostructure uptake, cancer drug delivery, and consequent cell killing. Formation of the DNA tube and its ability to arrange external elements into left- or right-handed form have been characterized by gel electrophoresis, atomic force microscopy, and transmission electron microscopy. Our fluorescence-based cell experiments showed that the DNA tube-templated aptamers of a left-handed pattern can yield a higher cell uptake than those in a right-form pattern. When loaded with an anticancer drug, Daunorubicin (Dau), the left-handed tube-aptamer-Dau construct showed greater than double the cancer cell cytotoxicity than the construct in the right-handed. Our study not only revealed that cell surface proteins interaction with the aptamers spatially organized into different chiral patterns can yield different cellular interaction and internalization efficiencies, but offered a new and versatile cancer drug delivery strategy for enhanced target cell treatment efficacy.
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