Evidence map›Paper›PMID 41546165›Full record

ArticlePhysiological reports2026

Inhibition of Rho-kinase restores impaired relaxation of airway smooth muscle in rat pups exposed to neonatal hyperoxia.

Ramadan B Sopi, Qëndrim Thaçi, Thomas M Raffay, Qëndresa Beqiraj-Zeqiraj

Abstract read
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In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ramadan B SopiDepartment of Premedical Courses, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Qëndrim ThaçiDepartment of Premedical Courses, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Thomas M RaffayDepartment of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA.
Qëndresa Beqiraj-ZeqirajDepartment of Pathophysiology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.

Funding

Ministry of Education, Science, Technology and Innovation in the Republic of Kosovo 2-1161-1Ministry of Education, Science, Technology and Innovation in the Republic of Kosovo 7042
6 · The paper itself

Abstract

Neonatal hyperoxia is a key contributor to bronchopulmonary dysplasia (BPD) which is characterized by airway hyperreactivity due to increased contraction and impaired relaxation of airway smooth muscle (ASM). This study investigated whether inhibition of the Rho/Rho-kinase signaling pathway restored tracheal smooth muscle (TSM) relaxation and reactivated the nitric oxide-guanosine 3',5'-cyclic monophosphate (NO-cGMP) pathway in neonatal rats exposed to hyperoxia. Newborn rats (P4) were exposed to either ambient air (AA; n = 61) or hyperoxia (FiO

Indexed as

HyperoxiaMuscle RelaxationMuscle, SmoothProtein Kinase Inhibitorsrho-Associated KinasesTrachea1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAmidesAnimalsAnimals, NewbornFemaleMaleNG-Nitroarginine Methyl EsterNitric OxidePyridinesRats1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAmidesfasudilNG-Nitroarginine Methyl EsterNitric OxideProtein Kinase InhibitorsPyridinesrho-Associated KinasesY 27632bronchopulmonary dysplasiafasudilneonatal hyperoxianitric oxideRho‐kinasetracheal smooth muscleY‐27632

Identifiers

PMID41546165
PMCPMC12811411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.