Evidence map›Paper›PMID 41546098›Full record

ArticleJournal of animal science and biotechnology2026

METTL3 regulates Leydig cell proliferation via miR-145-PCK1 mediated gluconeogenesis in goats.

Wen Tang, Maosheng Cao, Fengxin Qiao, Jinhong Luo, Yonghong Ju, Xiaodong Wang, Pengchen An, Wei Sun, Xiang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen TangKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China.
Maosheng CaoKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China. mscao@gzu.edu.cn.
Fengxin QiaoKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China.
Jinhong LuoKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China.
Yonghong JuKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China.
Xiaodong WangKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China.
Pengchen AnKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China.
Wei SunCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Xiang ChenKey Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China. xchen2@gzu.edu.cn.

Funding

Development of a Technical Support System for the Meat Sheep Industry in Guizhou Province (GZRYCYJSTX-02)Guizhou High- level Innovative Talents Project Qiankehe Platform Talents [2022] 021-1Guizhou Province Mutton Sheep Genetic Improvement and Innovative Utilization Science and Technology Innovation Talent Team Project QianKehe Platform Talent-CXTD[2023]025National Natural Science Foundation of China 32260835Natural Science Special Research Fund of Guizhou University ( (Gui Da Te Gang He Zi [2025] 12)
6 · The paper itself

Abstract

backgroundNormal testicular development is essential for maintaining male fertility and reproductive performance in livestock. Leydig cells (LCs) play a central role in testicular physiology; however, the epigenetic mechanisms regulating their development remain largely unclear. Methyltransferase-like 3 (METTL3), a key m

resultsMETTL3 expression in goat LCs markedly decreased during testicular development. This downregulation reduced m

conclusionsOur findings demonstrate that the METTL3/miR-145-3p/PCK1 axis is a key regulatory pathway linking epigenetic modification to the metabolic activity and proliferation of LCs. This mechanism provides novel insights into the molecular control of testicular development in male goats and may offer new targets for improving male reproductive capacity in livestock.

Indexed as

Leydig cellsMethyltransferase like 3MiR-145-3pPCK1Testicular development

Identifiers

PMID41546098
PMCPMC12811904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.