Evidence map›Paper›PMID 41546092›Full record

ArticleRadiation oncology (London, England)2026

Integrating static angle ports and dynamic collimator rotation in volumetric modulated arc therapy for hypofractionated whole breast irradiation in Chinese females: a single-centre dosimetric study.

Adams Hei Long Yuen, Matthew Shing Cheung Yik, Kenneth Tsz Hei Chung, Fuk Hay Tang, Christopher Wai Keung Lai, Yue Li, Yaqing Nong, Mingmei Tang, Zhen Zhang, Xingliu Wang and 5 more

Abstract read
In one paragraph

Article in Radiation oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Adams Hei Long YuenSchool of Medical and Health Sciences, Tung Wah College, Hong Kong Special Administrative Region, China. yhladams@gmail.com.ORCID http://orcid.org/0000-0001-9326-0247
Matthew Shing Cheung Yik *Department of Radiotherapy, Clinical Oncology Centre, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Kenneth Tsz Hei Chung *Varian Medical Systems Pacific, Inc., Hong Kong Special Administrative Region, China.
Fuk Hay TangSchool of Medical and Health Sciences, Tung Wah College, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0001-6530-7730
Christopher Wai Keung LaiSchool of Medical and Health Sciences, Tung Wah College, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0002-8010-7232
Yue LiDepartment of Radiotherapy, Clinical Oncology Centre, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Yaqing NongDepartment of Radiotherapy, Clinical Oncology Centre, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Mingmei TangDepartment of Radiotherapy, Clinical Oncology Centre, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Zhen ZhangApplication, Varian Medical Systems, Beijing, China.
Xingliu WangApplication, Varian Medical Systems, Beijing, China.
Xiaoshen WangApplication, Varian Medical Systems, Beijing, China.
Weihua ZhuApplication, Varian Medical Systems, Beijing, China.
Fuqiang ChenApplication, Varian Medical Systems, Beijing, China.
Alex Hoi Ning LeungDepartment of Radiology and Organ Imaging, United Christian Hospital, Hospital Authority, Hong Kong Special Administrative Region, China.
Jacky Tsz Lung WongSchool of Medical and Health Sciences, Tung Wah College, Hong Kong Special Administrative Region, China. jackywong@twc.edu.hk.ORCID http://orcid.org/0000-0002-5105-3423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhole breast irradiation remains the standard in breast-conserving therapy for early-stage carcinoma. Conventional RapidArc™ plans, while dosimetrically efficient, are limited by fixed collimator position. This often leads to unnecessary irradiation to adjacent organs at risk (OARs)—particularly the contralateral breast, ipsilateral lung, and cardiac structures—resulting in increased low-dose exposure. These challenges are exacerbated in Chinese female patients due to characteristic anatomical features, such as smaller, crescent-shaped breasts, and closer heart-to-target distances. The novel RapidArc Dynamic™ system provides dynamic collimator rotation and static angle ports, enabling more beam shaping during volumetric modulated arc therapy. This study evaluates the implementation of RapidArc Dynamic™ for whole breast irradiation, comparing its dosimetric performance against conventional RapidArc™ in Chinese female patients.

methodsTen patients with early-stage left breast cancer were retrospectively replanned using RapidArc™ and RapidArc Dynamic™ on Eclipse™ (v18.1). All plans employed 6-MV photons on a TrueBeam™ linear accelerator equipped with a Millennium 120-leaf MLC, prescribed to deliver 40 Gy in 15 fractions to breast planning target volume for evaluation. Dosimetric parameters for PTV and OARs were analyzed using Wilcoxon signed-rank test.

resultsThe results demonstrated that RapidArc Dynamic™ reduced contralateral breast exposure by 5.7% in maximum dose (29.6 Gy vs. 27.9 Gy) and 27.5% in mean dose (4.0 Gy vs. 2.9 Gy). Significant doses reductions in lungs were observed with a 13% lower mean lung dose (4.6 Gy vs. 4.0 Gy). Cardiac sparing improved with 21.6% lower mean heart dose (3.7 Gy vs. 2.9 Gy).

conclusionsRapidArc Dynamic™ demonstrates significant improvement in OARs sparing, despite anatomical challenges in Chinese female patients. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Breast NeoplasmsRadiation Dose HypofractionationRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedEast Asian PeopleFemaleHumansOrgans at RiskRadiotherapy DosageRetrospective StudiesDynamic collimatorRadiotherapyRapidArcRapidArc dynamicStatic angle portVolumetric modulated arc therapyWhole breast irradiation

Identifiers

PMID41546092
PMCPMC12874935

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.