ArticleBMC pharmacology & toxicology2026
Myricetin protects against doxorubicin-induced liver damage by modulating oxidative and inflammatory pathways.
Article in BMC pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDoxorubicin (Dox) is a highly effective chemotherapy drug used to treat various cancers. However, its clinical application is limited by liver toxicity, which is mainly caused by oxidative stress, inflammation, and mitochondrial damage. Myricetin, a natural flavonoid present in many fruits and vegetables, has demonstrated antioxidant and anti-inflammatory activities, making it a potential protective agent against such toxicity.
methodsThis study aimed to evaluate the protective effects of myricetin on Dox-induced liver damage in rats. Thirty-six male Sprague-Dawley rats were divided into six groups: a negative control, a Dox-only group (20 mg/kg, given intraperitoneally on day 10), a myricetin-only group (20 mg/kg, dissolved in corn oil, given orally for 10 days), high-dose (HD) myricetin + Dox (20 mg/kg), low-dose (LD) myricetin + Dox (10 mg/kg), and corn oil control. Biochemical, hematological, oxidative, and histological parameters were evaluated 24 h after Dox injection.
resultsDox increased serum alanine transaminase (75.6 ± 3.2 U/L), aspartate transaminase (237.6 ± 15.3 U/L), alkaline phosphatase (491.3 ± 16.4 U/L), liver-to-body weight ratio (4.38 ± 0.08%), total oxidant status (TOS, about two-fold compared to the control), and TNF-α (9.94 ± 0.82 U/mL), while decreasing total antioxidant capacity (T-AOC) by 35.2%, and bile acids by 24.0%. Myricetin coadministration, especially at higher doses, significantly reversed these changes. Histopathological evaluation confirmed myricetin's hepatoprotective effect, showing attenuation of hepatocellular degeneration, sinusoidal congestion, and inflammatory infiltration.
conclusionMyricetin demonstrated protective effects against Dox-induced liver damage through its antioxidant and anti-inflammatory properties. Further research is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.