Evidence map›Paper›PMID 41545907›Full record

ArticleParticle and fibre toxicology2026

Modulatory effects of CeO

Chang Guo, Alison Buckley, Sarah Robertson, Adam Laycock, Xianjin Cui, Eugenia Valsami-Jones, Tim Gant, Martin O Leonard, Rachel Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chang GuoToxicology Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate (RCE), UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK. chang.guo@ukhsa.gov.uk.
Alison BuckleyToxicology Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate (RCE), UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK.
Sarah RobertsonPublic Health Scotland (PHS), Gyle Square, 1 South Gyle Crescent, Edinburgh, EH12 9EB, UK.
Adam LaycockToxicology Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate (RCE), UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK.
Xianjin CuiSchool of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Eugenia Valsami-JonesSchool of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Tim GantToxicology Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate (RCE), UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK.
Martin O LeonardToxicology Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate (RCE), UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK.
Rachel SmithToxicology Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate (RCE), UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnderstanding the impacts of inhaled insoluble nanomaterials as they are encountered in the environment and workplace, in injured lungs remains limited, particularly with respect to their role in the progression or mitigation of lung pathology. While some studies suggest potential protective effects of cerium(IV) oxide nanoparticles (CeO

methodTo establish conditions of active pulmonary disease processes, bleomycin was used in both animal and airway epithelium models. Male Sprague-Dawley rats were intratracheally instilled with bleomycin or saline (control) followed by nose-only inhalation exposure to CeO

resultsIn vivo, bleomycin treatment resulted in an increase in total BAL cells and fibrotic staining, and significant induction of inflammatory and oxidative stress, as shown by mRNA sequencing analysis. One week of exposure to CeO

conclusionsIn this study, inhaled CeO

Indexed as

BleomycinCeriumLungNanoparticlesRespiratory MucosaAerosolsAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalHumansInhalation ExposureMaleParticle SizePulmonary FibrosisRatsRats, Sprague-DawleyAerosolsBleomycinceric oxideCeriumAir-liquid interface (ALI)BleomycinCeriumInhalationPulmonary disease process

Identifiers

PMID41545907
PMCPMC12829198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.