Evidence map›Paper›PMID 41545888›Full record

ArticleGenome biology2026

Exploring differences in the human gut microbiome between Han Chinese and non-Chinese populations.

Jingjing Wang, Zhenmiao Zhang, Yang Chen, Xi Zhou, Jiaxin Xiang, Chao Yang, Dmitry A Rodionov, Andrei L Osterman, Qinwei Qiu, Yusheng Deng and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Jingjing Wang *Department of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China.
Zhenmiao Zhang *Department of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China.
Yang Chen *State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xi ZhouDepartment of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China.
Jiaxin XiangDepartment of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China.
Chao YangDepartment of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China.
Dmitry A RodionovSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Andrei L OstermanSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Qinwei QiuState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yusheng DengState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yanmin LiuState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chengrui WangState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiaoxiao ShangState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Li HuangState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen SunState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Jianwen GuoState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhimin YangState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Lixiang ZhaiCentre for Chinese Herbal Medicine Drug Development Limited, Hong Kong Baptist University, Hong Kong SAR, China.
Zhaoxiang BianCentre for Chinese Herbal Medicine Drug Development Limited, Hong Kong Baptist University, Hong Kong SAR, China.
Aiping LyuSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Lijuan HanState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. hlj@kmhdgene.com.
Wei JiaDepartment of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China. weijia2@hku.hk.
Xiaodong FangState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. fangxd@gzucm.edu.cn.
Lu ZhangDepartment of Computer Science, Hong Kong Baptist University, Street, Hong Kong SAR, China. ericluzhang@hkbu.edu.hk.

Funding

REGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5M
HKBU RCMS RCMS/24-25/03HMRF grant No. 11221026National Natural Science Foundation of China No. 82004234NIDDK NIH HHS R01 DK030292Science and Technology Planning Project of Guangdong Province, China No. 2020B1111100005State Key Laboratory of Dampness Syndrome of Chinese Medicine No. SZ2024KF22Young Collaborative Research grant No. C2004-23Y
6 · The paper itself

Abstract

backgroundThe human gut microbiota exhibits significant diversity across populations, influenced by factors such as geography, diet, and lifestyle, particularly between the Han Chinese and non-Chinese populations. While previous studies have predominantly focused on the taxonomic abundance of the gut microbiome, the impact of single nucleotide polymorphisms (SNPs) in driving population-specific differences remains largely underexplored.

resultsIn this study, we systematically investigated gut microbial differences between the Han Chinese and non-Chinese populations using the Human Gut Microbiome Reference Genome Catalog (HGMRGC). We observed geography was the primary driver of microbial variation of abundance and SNPs. We identified 689 population-specific genome clusters from the Collinsella genus with functional differences in carbohydrate utilization and 108 species exhibiting distinct prevalence related to vitamin biosynthesis, antibiotic resistance, and carbohydrate metabolism. Beta diversity analysis highlighted significant inter-population differences in both microbial abundance and SNPs, while alpha diversity analysis revealed that non-Chinese populations exhibited higher diversity in microbial abundance, and Han Chinese populations displayed greater diversity in SNPs.

conclusionsThis study offers a comprehensive analysis of gut microbial differences between Han Chinese and non-Chinese populations, highlighting the profound influence of population-specific traits on microbial diversity and function. We also provide a comprehensive human gut microbial reference genome catalog, with a particular focus on the Han Chinese population, laying a foundation for future research on gut microbiota genomic variations.

Indexed as

East Asian PeopleGastrointestinal MicrobiomeChinaHumansPolymorphism, Single NucleotideHuman gut microbiomeMicrobial reference genomesPopulation differencesSingle nucleotide polymorphisms

Identifiers

PMID41545888
PMCPMC12895597

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