Evidence map›Paper›PMID 41545887›Full record

Trial reportJournal of neuroengineering and rehabilitation2026

Novel lower limb robot-assisted gait phase stimulation enhances walking and balance in stroke patients: a pilot trial.

Yixuan Huang, Yuting Tang, Zhanpeng Zhang, Longbin Shen, Zhenpeng Guo, Zhuoming Chen, Jinyi Long

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yixuan Huang *Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Xiamen, 361000, China.
Yuting Tang *Department of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, 613 West Huangpu Avenue, Tianhe District, Guangzhou, 510000, China.
Zhanpeng Zhang *Department of Dermatology, The first Affiliated Hospital of Jinan University, Guangzhou, 510000, China.
Longbin ShenDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, 613 West Huangpu Avenue, Tianhe District, Guangzhou, 510000, China.
Zhenpeng GuoCollege of Information Science and Technology, Jinan University, 601 West Huangpu Avenue, Tianhe District, Guangzhou, 510632, China.
Zhuoming ChenDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, 613 West Huangpu Avenue, Tianhe District, Guangzhou, 510000, China. zm120tchzm@qq.com.
Jinyi LongCollege of Information Science and Technology, Jinan University, 601 West Huangpu Avenue, Tianhe District, Guangzhou, 510632, China. jinyil@jnu.edu.cn.

Funding

National Natural Science Foundation of China No. 62276115Outstanding Youth Project of Guangdong Natural Science Foundation of China No. 2021B1515020076Science and Technology Planning Project of Guangdong Province 2023A0505050092the Guangzhou Basic and Applied Basic Research Foundation No. 2024A04J5486the Key Realm R&D Program of Guangdong Province 2019B030335001the National Key R&D Program of China 2020YFC2005700the Shanghai Municipal Health Commission Project 20234Y0140
6 · The paper itself

Abstract

backgroundHemiplegic patients often experience weakness in key muscle groups during gait, significantly impairing walking and balance. To address this, we developed a novel gait phase-specific functional electrical stimulation (FES) delivered through a lower limb rehabilitation robot. This pilot study investigated the effects of combining gait phase-specific FES with robot-assisted gait training (RAGT) in subacute stroke patients.

methodsFifty-one hemiplegic stroke patients were randomized into experimental, control, and placebo groups (17 each). The experimental group received conventional training plus gait phase-specific FES with RAGT. The control group underwent conventional training, traditional FES, and RAGT. The placebo group received conventional training with sham FES and RAGT. Interventions were administered daily, five times weekly, for three weeks. Assessments were conducted at baseline, weekly during treatment, and five weeks post-treatment completion. The primary outcomes were the 10-Meter Walk Test (10MWT) and the Berg Balance Scale (BBS). Secondary outcomes included the Fugl-Meyer Assessment (FMA-LE), the Manual Muscle Test (MMT), and the Modified Ashworth Scale (MAS).

resultsForty-eight patients completed the trial. Two-way repeated-measures ANOVA revealed significant time, group, and time × group interaction effects for primary outcomes (10MWT and BBS, P < 0.01). The experimental group showed significantly greater improvements in 10MWT versus control and placebo groups at week 2, 3, and 5th-week follow-up (P < 0.05). Similarly, BBS scores were highest in the experimental group at week 3 and follow-up (P < 0.01), with control also outperforming placebo (P < 0.05). Secondary outcomes (FMA-LE, MMT, MAS) improved across all groups (P < 0.0001), but the experimental group exhibited superior gains at the follow-up (P < 0.01). No significant differences were observed between control and placebo groups (P > 0.05).

conclusionsCombining gait phase-specific FES with RAGT can effectively improve walking and balance function in stroke patients.

Indexed as

Electric Stimulation TherapyGaitHemiplegiaLower ExtremityPostural BalanceRoboticsStroke RehabilitationAgedFemaleHumansMaleMiddle AgedPilot ProjectsStrokeTreatment OutcomeWalkingFunctional electrical stimulation (FES)Hemiplegic gaitLower limbRehabilitationStroke patients

Identifiers

PMID41545887
PMCPMC12892712

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.