Evidence map›Paper›PMID 41545778›Full record

ArticleNature biomedical engineering2026

Rotational ultrasound and photoacoustic tomography of the human body.

Yang Zhang, Shuai Na, Jonathan J Russin, Karteekeya Sastry, Li Lin, Junfu Zheng, Yilin Luo, Xin Tong, Yujin An, Peng Hu and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yang Zhang *Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Shuai Na *Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Jonathan J Russin *Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5304-4977
Karteekeya SastryCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-7659-4878
Li LinCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Junfu ZhengCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Yilin LuoCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-4611-3049
Xin TongCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Yujin AnCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Peng HuCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-2933-1239
Konstantin MaslovCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Tze-Woei TanKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6658-9482
Charles Y LiuDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. cliu@usc.edu.ORCID http://orcid.org/0000-0001-6423-8577
Lihong V WangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA. LVW@caltech.edu.ORCID http://orcid.org/0000-0001-9783-4383

Funding

Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brainU01EB029823 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, DANNY JJ, WANG, LIHONG · 2020 to 2024
$6.7M
High-speed panoramic 3D photoacoustic computed tomography of the breastR35CA220436 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, LIHONG · 2018 to 2024
$6.4M
Advancing Photoacoustic Tomography in breast imaging to predict response in breast cancers treated with neoadjuvant therapyR01CA282505 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Lily Lau Lai · 2023 to 2026
$2.6M
NCI NIH HHS R01 CA282505NCI NIH HHS R35 CA220436NIBIB NIH HHS U01 EB029823
6 · The paper itself

Abstract

Imaging the human body's morphological and angiographic information is essential for diagnosing, monitoring and treating medical conditions. Here we combine the power of ultrasonography for morphological assessment of soft tissue with photoacoustic tomography (PAT) for visualizing blood vessels to enable three-dimensional (3D) panoramic imaging. Specifically, fast panoramic rotational ultrasound tomography and PAT are integrated for hybrid rotational ultrasound and photoacoustic tomography (RUS-PAT), which obtains 3D ultrasound structural and PAT angiographic images of the human body quasi-simultaneously. The rotational ultrasound tomography functionality is achieved using a single-element ultrasonic transducer for ultrasound transmission and rotating arc-shaped arrays for 3D panoramic detection. By switching the acoustic source to a light source, the system is conveniently converted to PAT mode to acquire angiographic images in the same region. Using RUS-PAT, we successfully imaged the human head, breast, hand and foot with a 10-cm-diameter field of view, submillimetre isotropic resolution and 10 s imaging time for each modality. 3D RUS-PAT is a powerful tool for high-speed, dual-contrast imaging of the human body with potential for rapid clinical translation.

Identifiers

PMID41545778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.