Evidence map›Paper›PMID 41545705›Full record

ArticleAnnals of hematology2026

Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1.

Lunbi Wu, Peng Liu, Bowen Jiang, Xiaodong Zhang, Enliang Zhao, Jingying Zhao, Fangxu Zhu, Hongxin Xu, Kuo Shi, Baiyu Jian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lunbi Wu *Qiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Peng Liu *Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China.
Bowen JiangQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Xiaodong ZhangQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Enliang ZhaoQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Jingying ZhaoQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Fangxu ZhuQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Hongxin XuQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Kuo ShiQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China.
Baiyu JianQiqihar Medical University, NO. 333 Bukui North Street, Qiqihar, Heilongjiang, 161000, China. jianbaiyu@qmu.edu.cn.

Funding

the Clinical Research Fund Project of Qiqihar Academy of Medical Sciences QMSI2024L-10
6 · The paper itself

Abstract

To clarify the biological roles of the putative target thrombospondin-1 (THBS1) and the impact of the traditional Chinese medicine monomer Lycorine on acute myeloid leukemia (AML) cells. The AML cell lines HL-60 and THP-1 were used in vitro to assess the effects of lycorine on cell growth and apoptosis. Network pharmacology and Gene Expression Omnibus (GEO) database analysis were used to predict potential lycorine targets in AML. Clinical samples were used to validate the target THBS1's expression. The binding affinity between lycorine and THBS1 was examined using molecular docking. Lastly, THBS1 overexpression in AML cells confirmed its function. In a dose-dependent way, lycorine induced apoptosis and markedly suppressed the growth of AML cell lines. THBS1 is a common target of lycorine in AML, and its expression is dramatically downregulated in AML, according to network pharmacology, GEO database analysis, and confirmation using clinical samples. Lycorine's ability to bind to THBS1 and increase its expression levels in AML cells was validated by molecular docking. In AML cells, THBS1 overexpression mirrored the effects of lycorine by preventing cell division and triggering apoptosis. Lycorine inhibits the growth of AML cells and triggers apoptosis by targeting and upregulating the expression of THBS1. Therefore, it has antileukemic actions. One of the main targets for anti-AML treatment is THBS1.

Indexed as

Amaryllidaceae AlkaloidsCell ProliferationGene Expression Regulation, LeukemicLeukemia, Myeloid, AcuteNeoplasm ProteinsPhenanthridinesThrombospondin 1Up-RegulationApoptosisHL-60 CellsHumansMolecular Docking SimulationTHP-1 CellsAmaryllidaceae AlkaloidslycorineNeoplasm ProteinsPhenanthridinesThrombospondin 1thrombospondin-1, humanAcute myeloid leukemiaLycorineMolecular dockingNetwork pharmacologyTHBS1

Identifiers

PMID41545705
PMCPMC12811170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.