Evidence map›Paper›PMID 41545703›Full record

ArticleCommunications biology2026

haCCA: multi-module Integration of spot-based spatial transcriptomes and metabolomes.

Jing Xu, Xiao-Tian Shen, Chen Zhang, Xiao-Yun Zhang, Zhou-Qing Chen, Hu-Liang Jia, Lu-Yu Yang

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing Xu *Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0004-7045-8161
Xiao-Tian Shen *Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Chen Zhang *Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Xiao-Yun ZhangMicrosoft Co Seattle, Seattle, WA, USA.
Zhou-Qing ChenDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China. zqchen6@163.com.
Hu-Liang JiaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, China. jbl-1@163.com.
Lu-Yu YangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China. yangluyu@huashan.org.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82201445Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 24ZR1408800
6 · The paper itself

Abstract

Spatial transcriptomes and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) measures mRNA expression and mass-to-charge (m/z) spectra on thousands of spots along with the spatial coordinates. Integrating spatial transcriptomes and MALDI-MSI is challenge due to no shared coordinates or features. We present

Indexed as

MetabolomeSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTranscriptomeAnimalsGene Expression ProfilingMultiomicsSpatial Transcriptomics

Identifiers

PMID41545703
PMCPMC12905351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.